Evidence map›Paper›PMID 32839735›Full record

ArticleMolecular therapy oncolytics2020

Oncolytic Virus with Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers.

Bolni Marius Nagalo, Camilo Ayala Breton, Yumei Zhou, Mansi Arora, James M Bogenberger, Oumar Barro, Michael B Steele, Nathan J Jenks, Alexander T Baker, Dan G Duda and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  4. Article
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  8. Oncolytic viral vectors in the era of diversified cancer therapy: from preclinical to clinical.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Bolni Marius NagaloDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Camilo Ayala BretonDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Yumei ZhouDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Mansi AroraDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
James M BogenbergerDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Oumar BarroDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Michael B SteeleDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Nathan J JenksDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Alexander T BakerDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Dan G DudaDepartment of Radiation Oncology, Steele Laboratories for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Lewis Rowland RobertsDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Stephen J RussellDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Kah Whye PengDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Mitesh J BoradDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Mayo Clinic in Arizona · USHarvard University · USMayo Clinic · US

Funding

Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI MARK A. MC NIVEN · 2018 to 2026
$20.5M
Oncolytic Virotherapy in Hepatocellular CancerDP2CA195764 · NCI · MAYO CLINIC ARIZONA · PI BORAD, MITESH · 2014 to 2016
$2.7M
Intravenous Administration of Vesicular Stomatitis VectorsR01CA175795 · NCI · MAYO CLINIC ROCHESTER · PI PENG, KAH-WHYE · 2014 to 2017
$1.5M
cGAS-STING Pathway Targeting Replicative Adenoviruses with CD46 Tropism and AFP Promoter Conditional Replication Restriction for the Treatment of Hepatocellular CarcinomaK01CA234324 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NAGALO, BOLNI MARIUS · 2018 to 2022
$667k
Phase 1 Study of VSV-hIFN-B for the Treatment of Hepatocellular CarcinomaR01FD004781 · FDA · MAYO CLINIC ARIZONA · PI BORAD, MITESH · 2014 to 2016
$399k
FDA HHS R01 FD004781NCI NIH HHS DP2 CA195764NCI NIH HHS K01 CA234324NCI NIH HHS P50 CA210964NCI NIH HHS R01 CA175795
6 · The paper itself

Abstract

Recombinant vesicular stomatitis virus (VSV)-fusion and hemagglutinin (FH) was developed by substituting the promiscuous VSV-G glycoprotein (G) gene in the backbone of VSV with genes encoding for the measles virus envelope proteins F and H. Hybrid VSV-FH exhibited a multifaceted mechanism of cancer-cell killing and improved neurotolerability over parental VSV in preclinical studies. In this study, we evaluated VSV-FH

Indexed as

cholangiocarcinomahepatobiliary cancerhepatocellular carcinomameasles virusoncolytic viral therapypancreatic cancervesicular stomatitis virus

Identifiers

PMID32839735
PMCPMC7437509
OpenAlexW3062648467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.