ReviewRestorative dentistry & endodontics2020
The effect of root canal irrigants on dentin: a focused review.
Review in Restorative dentistry & endodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Can natural irrigants replace sodium hypochlorite? A systematic review.Clinical oral investigations · 2023Pooled it
- Effect of Endodontic Irrigation on Mineral Content of Root Canal Dentine: A Systematic Review and Meta-Analysis.European endodontic journal · 2023Pooled it
- Irrigating Solutions and Activation Methods Used in Clinical Endodontics: A Systematic Review.Frontiers in oral health · 2022Pooled it
- Article
- Chitosan-coated gold nanostars with photothermal activity for enhanced disinfection efficacy of sodium hypochlorite in antibacterial-based root canal therapy.BMC chemistry · 2026Article
- Article
- Enhanced Cleaning, Enhanced Healing: A Systematic Review of Advances in Endodontic Irrigation.Journal of pharmacy & bioallied sciences · 2025Article
- Effect of phthalocyanine, methylene blue and toluidine blue photosensitizers on the adhesive interface of fiber posts: a confocal laser microscopy study.Lasers in medical science · 2025Article
- Review
- Endodontic irrigants from a comprehensive perspective.World journal of clinical cases · 2024Review
- Effect of herbal irrigants on surface roughness of intraradicular dentin using quantitative method of 3D surface texture analysis.Scientific reports · 2024Article
- Impact of calcium hydroxide and 2-hydroxyisocaproic acid on the microhardness of root dentine: an in vitro study.Odontology · 2024Article
- Effect of ultrasonic and Er,Cr:YSGG laser-activated irrigation protocol on dual-species root canal biofilm removal: AnJournal of conservative dentistry and endodontics · 2024Article
- Effect of Different Irrigating Solutions on Root Canal Dentin Microhardness-A Systematic Review with Meta-Analysis.Journal of functional biomaterials · 2024Review
- Effect of different root canal irrigants on surface roughness and microhardness of Biodentine combined with triple antibiotic paste: AnJournal of conservative dentistry and endodontics · 2024Article
- Mechanical properties of simulated dentin caries treated with metal cations and L-ascorbic acid 2-phosphate.Odontology · 2024Article
- Exploring Periostracum as an Alternative Root Canal Irrigant: Insights From Zebrafish Embryo Experiments.Cureus · 2024Article
- Comparative Evaluation of Dental Pulp Tissue Dissolution Ability of Sapindus mukorossi and Sodium Hypochlorite.Cureus · 2024Article
- Dual- or single rinse? The tubular sealer penetration of endodontic chelating agents.PloS one · 2024Article
- Minimally invasive management of vital teeth requiring root canal therapy.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the vast literature on the effects of root canal irrigants on the dentin characteristics, the precise effects of clinically relevant irrigation sequences remain unclear. In this review, we systematically dissect the role of different sequential irrigation approaches that are used in clinical endodontics. Using a systematic search strategy, we attempt to answer the question: 'Which irrigating sequence has the most deleterious effects on dentin structure and properties?' The effect of irrigants on the dentin composition and mechanical properties have been reviewed. A wide variety of concentrations, duration and techniques have been employed to characterize the effects of chemicals on dentin properties, thus making it impossible to draw guidelines or recommendations of irrigant sequences to be followed clinically. It was apparent that all the studied irrigation sequences potentially result in some deleterious effects on dentin such as decrease in the flexural strength, microhardness, modulus of elasticity and inorganic content and organic-inorganic ratio of the dentin. However, the literature still lacks comprehensive investigations to compare the deleterious effect of different irrigation sequences, using a wide variety of qualitative and quantitative methods. Such investigations are essential to make clinical recommendations and strategize efforts to minimize chemically-induced damage to dentin characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.