ReviewRestorative dentistry & endodontics2020
Calcium silicate-based root canal sealers: a literature review.
Review in Restorative dentistry & endodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 126 citations in OpenAlex.
- Short-term radiographic changes of extruded NeoSealer Flo in a simulated enlarged-apex model: influence of moisture and periapical support.Clinical oral investigations · 2026Article
- Clinical and Radiographic Outcomes Following Unintentional Extrusion of Cold Ceramic: A Case Series of Three Patients.Clinical case reports · 2026Article
- Clinical and radiological outcomes of Thermafil Plus used with bioceramic versus epoxy-resin sealer: results from a 12-month randomized clinical trial.Odontology · 2026Article
- Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study.Clinical oral investigations · 2026Article
- In Vitro Comparison of Void Formation Between Calcium Silicate-Based Sealers and AH Plus: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Article
- Review
- Influence of calcium hydroxide/nano-chitosan as intracanal medication on push-out bond strength of epoxy resin and bioceramic sealers: an ex-vivo study.BMC oral health · 2026Article
- Article
- Dentin tubule penetration of a calcium silicate-based sealer after removal of calcium hydroxide or N-acetylcysteine medicaments: an in vitro study.BMC oral health · 2026Article
- Physiochemical properties of premixed bioceramic-based root canal sealer reinforced with copper oxide nanoparticles.Journal of conservative dentistry and endodontics · 2026Article
- In Vitro Assessment of Osteogenic Modulation and Molecular Responses Induced by Contemporary Endodontic Sealers in MC3T3-E1 Pre-Osteoblasts.Dentistry journal · 2026Article
- Effects of interactions between sealers and irrigants on the physicochemical and surface characteristics of endodontic sealers.Clinical oral investigations · 2026Article
- Impact of acidic pH and sealer thickness on the physical behavior of endodontic sealers: a micro-CT study.Brazilian oral research · 2026Article
- Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- Functional and Bioactive Performance of Premixed Bioceramic Sealers with Warm Obturation: A Scoping Review.Gels (Basel, Switzerland) · 2025Review
- Multispecies Biofilms Treated With Endodontic Sealers or Calcium Hydroxide: Antimicrobial Activity and Changes in Community Composition.International endodontic journal · 2025Article
- Influence of different endodontic treatment protocols on tooth survival: A retrospective cohort study with multistate analysis and group balancing.International endodontic journal · 2025Article
- A comparative analysis of adhesion abilities between AH PlusJournal of conservative dentistry and endodontics · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epoxy resin-based sealers are currently widely used, and several studies have considered AH Plus to be the gold-standard sealer. However, it still has limitations, including possible mutagenicity, cytotoxicity, inflammatory response, and hydrophobicity. Drawing upon the advantages of mineral trioxide aggregate, calcium silicate-based sealers were introduced with high levels of biocompatibility and hydrophilicity. Because of the hydrophilic environment in root canals, water resorption and solubility of root canal sealers are important factors contributing to their stability. Sealers displaying lower microleakage and stronger push-out bond strength are also needed to endure the dynamic tooth environment. Although the physical properties of calcium silicate-based sealers meet International Organization for Standardization recommendations, and they have consistently reported to be biocompatible, they have not overcome conventional resin-based sealers in actual practice. Therefore, further studies aiming to improve the physical properties of calcium silicate-based sealers are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.