ReviewRestorative dentistry & endodontics2020
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion.
Review in Restorative dentistry & endodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.Odontology · 2025Pooled it
- Pooled it
- Coadministration of fluoride, trimetaphosphate, and quercetin reduces dentin erosive wear in vitro.Clinical oral investigations · 2026Article
- Bond strength and interfacial stability of a universal adhesive to alendronate-treated dentin.Scientific reports · 2026Article
- Phytic acid and grape seed extract in dentin biomodification: effects on bond strength and interface integrity.Frontiers in dental medicine · 2026Article
- Marginal integrity produced by quaternary ammonium methacrylate-based dental adhesive tested under physiologically relevant models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Riboflavin-Mediated Photodynamic Therapy in Periodontology: A Systematic Review of Applications and Outcomes.Pharmaceutics · 2025Review
- Impact of silver diamine fluoride on composite resin bond strength: An In vitro study with various adhesive systems.Heliyon · 2025Article
- In Situ Zymography in Formalin-Fixed Paraffin-Embedded and Mineralized Tissues.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements.Journal of functional biomaterials · 2024Article
- Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications.Dental materials : official publication of the Academy of Dental Materials · 2024Review
- Effect of MMP Inhibitors on Shear Bond Strength of Adhesive to Dentin after Different Drying Techniques: AnJournal of pharmacy & bioallied sciences · 2024Article
- Long-term hybrid stability and matrix metalloproteinase inhibition by fucosterol in resin-dentin bonding biomechanics.Scientific reports · 2024Article
- Effect of nonthermal atmospheric plasma application at different time intervals on the dentinal shear bond strength pretreated with 2% chlorhexidine as cavity disinfectant: AnJournal of conservative dentistry and endodontics · 2024Article
- Article
- Dentine biomodification by sulphonamides pre-treatment: bond strength, proteolytic inhibition, and antimicrobial activity.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification.Journal of dental sciences · 2023Article
- Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface.Frontiers in dental medicine · 2023Review
- The Role of Duration of Chlorhexidine Gluconate 2% Application on the Shear Bond Strength of a Total Etch Bonding Agent: A Comparative Study.Clinical, cosmetic and investigational dentistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were "matrix metalloproteinases", "collagen", and "dentin" and "hybrid layer". MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.