ArticleNature immunology2020
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 144 papers.
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144citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
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Who cites it
144 citing papers in PubMed, 214 citations in OpenAlex.
- Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade.Cancer discovery · 2025Trial
- Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Trial
- Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy.Journal for immunotherapy of cancer · 2022Trial
- Immune signatures underlying post-acute COVID-19 lung sequelae.Science immunology · 2021Trial
- Fast and slow gene expression changes in blood following acute social stress.Brain, behavior, & immunity - health · 2026Article
- scURL: uncertainty-sharpened representation learning for single-cell multi-omics clustering.Bioinformatics (Oxford, England) · 2026Article
- Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes.The Journal of clinical investigation · 2026Article
- Exploring the functions of NKG7 in CD4+ and CD8+ T cells during malaria.PLoS pathogens · 2026Article
- Ascites reprograms innate lymphoid immune cells in ovarian cancer by promoting ILC2 enrichment and dysfunctional NK-cell states.Journal for immunotherapy of cancer · 2026Article
- Exercise-Mobilized Donor Lymphocytes Enhance Blinatumomab Activity Against B-ALL.Research square · 2026Article
- Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis.mBio · 2026Article
- Cytotoxic CD4Parasite immunology · 2026Article
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells.PLoS pathogens · 2026Article
- Circulating natural killer cells are phenotypically and functionally altered in age-related macular degeneration.Cell reports. Medicine · 2026Article
- Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging.Nature communications · 2026Article
- Glycan atlassing enables functional tracing of cell state.Nature nanotechnology · 2026Article
- Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells.bioRxiv : the preprint server for biology · 2026Article
- Aberrant immune regulation and enrichment of stem-like CD8bioRxiv : the preprint server for biology · 2026Article
- Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis.Journal of advanced research · 2026Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
49 authors at 13 institutions in 6 countries.
Susanna S NgQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-8494-7722
Fabian De Labastida RiveraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Juming YanQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Dillon CorvinoQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-0683-1369
Indrajit DasQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-8407-9796
Ping ZhangQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0311-6725
Rachel KunsQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Shashi Bhushan ChauhanDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.ORCID http://orcid.org/0000-0002-3268-852X
Jiajie HouQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Xian-Yang LiQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Teija C M FrameQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0937-4231
Benjamin A McEnroeQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Eilish MooreQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-3745-5781
Jinrui NaQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0134-5970
Jessica A EngelQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Megan S F SoonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bhawana SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Andrew J KuehDivision of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Marco J HeroldDivision of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Marcela Montes de OcaQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Siddharth Sankar SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Patrick T BunnQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Amy Roman AguileraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mika CaseyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Matthias BraunQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nazanin GhazanfariDepartment of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Shivangi WaniQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Yulin WangQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9976-5315
Fiona H AmanteQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Chelsea L EdwardsQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ashraful HaqueQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
William C DougallQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Om Prakash SinghDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India.ORCID http://orcid.org/0000-0003-2146-8107
Alan G BaxterCollege of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
Michele W L TengQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Alex LoukasAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Norelle L DalyAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Nicole CloonanQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mariapia A Degli-EspostiInfection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Jude UzonnaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
William R HeathDepartment of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9670-259X
Tobias BaldQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-0061-235X
Siok-Keen TeyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-9567-382X
Kyohei NakamuraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-6631-9028
Geoffrey R HillClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Rajiv KumarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.ORCID http://orcid.org/0000-0003-2338-1494
Shyam Sundar *Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Mark J Smyth *QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7098-7240
Christian R Engwerda *QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. chrisE@qimr.edu.au.ORCID http://orcid.org/0000-0003-2813-4804
QIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUInstitute of Medical Sciences · INThe University of Melbourne · AUGriffith University · AUAustralian Institute of Tropical Health and Medicine · AUBanaras Hindu University · INFred Hutch Cancer Center · USJames Cook University · AULions Eye Institute · AUUniversity of Auckland · NZUniversity of Bonn · DEUniversity of Manitoba · CA
Funding
Visceral Leishmaniasis in Bihar State, IndiaP50AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2007 to 2016
$6.4MVisceral Leishmaniasis in Bihar State, IndiaU19AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2017 to 2021
$2.8MNIAID NIH HHS P50 AI074321NIAID NIH HHS U19 AI074321
Abstract
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCytotoxicity, ImmunologicDisease Models, AnimalExocytosisHumansInflammationKiller Cells, NaturalLeishmania donovaniLeishmaniasis, VisceralMalariaMembrane ProteinsMiceMice, Inbred C57BLMembrane ProteinsNkg7 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.