Evidence map›Paper›PMID 32839580›Full record

ReviewNature reviews. Nephrology2020

Challenges and novel therapies for vascular access in haemodialysis.

Jeffrey H Lawson, Laura E Niklason, Prabir Roy-Chaudhury

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06632132 (Boosting Knowledge, Attitudes, and Practices), which is not on this map. Cited by 82 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 4 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06632132 nacompletednot on this mapstarted 2024, after this paper: background citation

Boosting Knowledge, Attitudes, and Practices: An Experimental Study Evaluating the Effectiveness of mHealth Training on Antimicrobial Resistance for Hemodialysis Nurses

TypeinterventionalSponsorJordan University of Science and TechnologyRan2024 to 2024Enrolled64ConditionsAntimicrobial Resistance in HemodialysisArmsAntimicrobial resistance Training in Hemodialysis Units
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  20. Evaluation and comparison of patency rate and complications of synthetic arteriovenous grafts in the groin and upper extremities among hemodialysis patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
    Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jeffrey H LawsonDepartment of Surgery, Duke University, Durham, NC, USA. jeffrey.lawson@duke.edu.
Laura E NiklasonHumacyte, Inc., Durham, NC, USA.
Prabir Roy-ChaudhuryUniversity of North Carolina Kidney Center, Chapel Hill, NC, USA.
Duke University · USHumacyte (United States) · USW. G. (Bill) Hefner VA Medical Center · US

Funding

Biologically Selective Drug-Eluting StentR01HL148819 · NHLBI · YALE UNIVERSITY · PI SALTZMAN, WILLIAM · 2019 to 2022
$2.7M
NHLBI NIH HHS R01 HL148819
6 · The paper itself

Abstract

Advances in standards of care have extended the life expectancy of patients with kidney failure. However, options for chronic vascular access for haemodialysis - an essential part of kidney replacement therapy - have remained unchanged for decades. The high morbidity and mortality associated with current vascular access complications highlights an unmet clinical need for novel techniques in vascular access and is driving innovation in vascular access care. The development of devices, biological approaches and novel access techniques has led to new approaches to controlling fistula geometry and manipulating the underlying cellular and molecular pathways of the vascular endothelium, and influencing fistula maturation and formation through the use of external mechanical methods. Innovations in arteriovenous graft materials range from small modifications to the graft lumen to the creation of completely novel bioengineered grafts. Steps have even been taken to create new devices for the treatment of patients with central vein stenosis. However, these emerging therapies face difficult hurdles, and truly creative approaches to vascular access need resources that include well-designed clinical trials, frequent interaction with regulators, interventionalist education and sufficient funding. In addition, the heterogeneity of patients with kidney failure suggests it is unlikely that a 'one-size-fits-all' approach for effective vascular access will be feasible in the current environment.

Indexed as

InventionsVascular Access DevicesCentral Venous CathetersHumansRenal Dialysis

Identifiers

PMID32839580
PMCPMC8108319
OpenAlexW3080128432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.