Evidence map›Paper›PMID 32839576›Full record

ReviewNature reviews. Genetics2020

The road ahead in genetics and genomics.

Amy L McGuire, Stacey Gabriel, Sarah A Tishkoff, Ambroise Wonkam, Aravinda Chakravarti, Eileen E M Furlong, Barbara Treutlein, Alexander Meissner, Howard Y Chang, Núria López-Bigas and 2 more

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Bioethics of somatic gene therapy: what do we know so far?Current medical research and opinion · 2023
    Pooled it
  2. Pooled it
  3. Current profile of Charcot-Marie-Tooth disease in Africa: A systematic review.Journal of the peripheral nervous system : JPNS · 2022
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Personalized Medicine in Treating Rare Genetic Disorders: A Review.Journal of pharmacy & bioallied sciences · 2025
    Review
  15. Mapping the knowledge landscape of the PET/MR domain: a multidimensional bibliometric analysis.European journal of nuclear medicine and molecular imaging · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amy L McGuireCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA. amcguire@bcm.edu.
Stacey GabrielBroad Institute of MIT and Harvard, Cambridge, MA, USA. stacey@broadinstitute.org.
Sarah A TishkoffDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA. tishkoff@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1339-5959
Ambroise WonkamDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.ORCID http://orcid.org/0000-0003-1420-9051
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY, USA. aravinda.chakravarti@nyulangone.org.ORCID http://orcid.org/0000-0002-4264-2285
Eileen E M FurlongEuropean Molecular Biology Laboratory, Genome Biology Department, Heidelberg, Germany. furlong@embl.de.ORCID http://orcid.org/0000-0002-9544-8339
Barbara TreutleinDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.ORCID http://orcid.org/0000-0002-3299-5597
Alexander MeissnerBroad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.ORCID http://orcid.org/0000-0001-8646-7469
Howard Y ChangCenter for Personal Dynamic Regulomes, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. howchang@stanford.edu.ORCID http://orcid.org/0000-0002-9459-4393
Núria López-BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. nuria.lopez@irbbarcelona.org.ORCID http://orcid.org/0000-0003-4925-8988
Eran SegalDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.ORCID http://orcid.org/0000-0002-6859-1164
Jin-Soo KimCenter for Genome Engineering, Institute for Basic Science, Daejon, Republic of Korea. jskim01@snu.ac.kr.ORCID http://orcid.org/0000-0003-4847-1306

Funding

Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8M
Sickle Africa Data Coordinating CenterU24HL135600 · NHLBI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA, WONKAM, AMBROISE · 2017 to 2025
$8.6M
LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
Genetic Analysis of Hirschsprung DiseaseR37HD028088 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2010 to 2019
$6.2M
Genetic and molecular basis for variation in human skin pigmentationR01AR076241 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI MARKS, MICHAEL S, OANCEA, ELENA · 2020 to 2024
$5.5M
Integrative Genomic Analyses of Human Evolution and Adaptation in AfricaR35GM134957 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2020 to 2024
$2.7M
Return of a Fragile X Syndrome genetic result: exploring the feedback of individual genetic findings and their relation to traditional knowledge in a village in Cameroon.U54HG009790 · NHGRI · UNIVERSITY OF CAPE TOWN · PI WONKAM, AMBROISE · 2017 to 2021
$2.5M
Hearing Impairment Genetics Studies in Africa (HI-GENES Africa)U01HG009716 · NHGRI · UNIVERSITY OF CAPE TOWN · PI WONKAM, AMBROISE · 2017 to 2021
$1.2M
Exploring Perspectives on Genomics and Sickle Cell Public Health InterventionsU01HG007459 · NHGRI · UNIVERSITY OF CAPE TOWN · PI WONKAM, AMBROISE · 2013 to 2016
$622k
Howard Hughes Medical InstituteNCI NIH HHS R35 CA209919NHGRI NIH HHS P50 HG007735NHGRI NIH HHS RM1 HG007735NHGRI NIH HHS U01 HG007459NHGRI NIH HHS U01 HG009716NHGRI NIH HHS U54 HG009790NHLBI NIH HHS U24 HL135600NIAMS NIH HHS R01 AR076241NICHD NIH HHS R37 HD028088NIGMS NIH HHS R35 GM134957Wellcome TrustWellcome Trust H3A/18/001
6 · The paper itself

Abstract

In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading researchers to reflect on the key challenges and opportunities faced by the field of genetics and genomics. Keeping their particular research area in mind, they take stock of the current state of play and emphasize the work that remains to be done over the next few years so that, ultimately, the benefits of genetic and genomic research can be felt by everyone.

Indexed as

Genome, HumanGenome-Wide Association StudyDiseaseGeneticsGenomicsHumans

Identifiers

PMID32839576
PMCPMC7444682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.