Evidence map›Paper›PMID 32839519›Full record

Observational studySpinal cord2021

Serum albumin as a predictor of neurological recovery after spinal cord injury: a replication study.

Anh K Vo, Fred Geisler, Lukas Grassner, Jan Schwab, Gale Whiteneck, Catherine Jutzeler, John L K Kramer

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Spinal cord, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Immediate administration of hTERT-MSCs-IDO1-EVs reduces hypoalbuminemia after spinal cord injury.Veterinary research forum : an international quarterly journal · 2024
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Anh K VoInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Fred GeislerUniversity of Saskatchewan, Saskatoon, SK, Canada.
Lukas GrassnerCenter for Spinal Cord Injuries, BG Trauma Center Murnau, Murnau, Germany.ORCID http://orcid.org/0000-0002-3390-0895
Jan SchwabBelford Center for Spinal Cord Injury and Department of Neurology (Paraplegiology), Wexner Medical Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6784-4919
Gale WhiteneckCraig Hospital, Research Department, Englewood, CO, USA.
Catherine Jutzeler *International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-7167-8271
John L K Kramer *International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. kramer@icord.org.
University of British Columbia · CACraig Hospital · USInnsbruck Medical University · ATThe Ohio State University Wexner Medical Center · USUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designThis was a secondary analysis on an observational cohort study.

objectiveTo determine if serum albumin significantly associates with long-term neurological outcome (i.e., 1-year post-injury) in a contemporary cohort of individuals with spinal cord injury.

settingSix rehabilitation centers across the United States.

methodsA secondary analysis of neurological outcomes and serum albumin concentrations was performed on data from the Spinal Cord Injury Rehabilitation study. Data was accessed from the Archive of Data on Disability to Enable Policy and research (ADDEP). The primary analysis applied unbiased recursive partitioning to examine the relationship between serum albumin, injury severity, and long-term outcomes. The analysis is accessible via https://rpubs.com/AnhKhoaVo/586028 .

resultsSerum albumin concentration was significantly associated with lower extremity motor scores (LEMS) and American Spinal Injury Association Impairment Scale (AIS) grade at admission to rehabilitation. Serum albumin concentrations alone were also significantly associated with change of LEMS and marked recovery (improvement of at least 2 AIS grades and/or recovery to walking) at 1-year post injury. However, after adjusting for admission to rehabilitation LEMS and AIS grade, serum albumin was not significant.

conclusionThe current study partially confirms our previous observations that serum albumin concentrations are associated with neurological outcome after spinal cord injury. As a crude prognostic biomarker, serum albumin concentration could be useful in cases where injury severity cannot be accurately assessed.

Indexed as

Serum AlbuminSpinal Cord InjuriesCohort StudiesHumansRecovery of FunctionWalkingSerum Albumin

Identifiers

PMID32839519
OpenAlexW3080575893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.