Evidence map›Paper›PMID 32839355›Full record

ArticleKidney research and clinical practice2020

Ferric carboxymaltose versus ferric gluconate in hemodialysis patients: Reduction of erythropoietin dose in 4 years of follow-up.

Antonio Lacquaniti, Patrizio Pasqualetti, Teresa Casuscelli di Tocco, Susanna Campo, Stefania Rovito, Maurizio Bucca, Antonino Ragusa, Paolo Monardo

Open access · diamondAbstract read
In one paragraph

Article in Kidney research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Antonio LacquanitiNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0003-1705-8770
Patrizio PasqualettiService of Medical Statistics & IT (SeSMIT), Fatebenefratelli Foundation for Health Research and Education, Rome, Italy.ORCID https://orcid.org/0000-0001-5560-1979
Teresa Casuscelli di ToccoNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0001-8533-1594
Susanna CampoNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0002-1465-1096
Stefania RovitoNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0003-1637-3285
Maurizio BuccaNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0001-9382-1470
Antonino RagusaNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0001-7269-4230
Paolo MonardoNephrology and Dialysis Unit, Papardo Hospital, Messina, Italy.ORCID https://orcid.org/0000-0002-0492-5022
Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte · ITFatebenefratelli Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFerric carboxymaltose (FCM) is a parenteral, dextran-free iron formulation designed to overcome the limitations of existing iron preparations. The main aim of this study was to retrospectively examine results obtained from a long period of FCM therapy in hemodialysis patients who have been previously treated with ferric gluconate (FX). Markers of iron metabolism, erythropoietin (EPO) doses, and effects on anemic status have been analysed.

methodsThe study was performed with a follow up period of 4 years, when patients were treated before with FX and then switched to FCM. A total of 25 patients were included in the study.

resultsFCM increased transferrin saturation (TSAT) levels by 11.9% (

conclusionDuring FCM treatment, minor doses of EPO were administered if compared to those delivered during FX therapy. Stable and on target levels of hemoglobin were maintained with better control of anemia through high levels of ferritin and TSAT.

Indexed as

AnemiaErythropoietin resistance indexFerric carboxymaltoseHemodialysis

Identifiers

PMID32839355
PMCPMC7530360
OpenAlexW3081503398

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.