ArticleDiabetes2020
Structural Alterations in Deep Brain Structures in Type 1 Diabetes.
Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.Metabolic brain disease · 2026Article
- Disrupted neurovascular-endocrine coupling in type 1 diabetes with impaired awareness of hypoglycemia.The Journal of clinical investigation · 2026Article
- The virtual Morris water maze for cognitive function assessment in adolescents with type 1 diabetes.Diabetologia · 2026Article
- Cognitive flexibility is associated with the age of onset and duration among patients with type 1 diabetes.Scientific reports · 2025Article
- Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation.Acta pharmacologica Sinica · 2024Article
- Network medicine-based epistasis detection in complex diseases: ready for quantum computing.Nucleic acids research · 2024Article
- Cerebral Small Vessel Disease Is Associated With Smaller Brain Volumes in Adults With Type 1 Diabetes.Journal of diabetes research · 2024Article
- Case report: Ketogenic diet alleviated anxiety and depression associated with insulin-dependent diabetes management.Frontiers in nutrition · 2024Article
- Network medicine-based epistasis detection in complex diseases: ready for quantum computing.medRxiv : the preprint server for health sciences · 2023Article
- Different FreeSurfer versions might generate different statistical outcomes in case-control comparison studies.Neuroradiology · 2022Article
- Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment.Frontiers in endocrinology · 2022Article
- Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice.Microbiome · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 5 countries.
Funding
Abstract
Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this disease, we sought to determine the possible neural correlate in long-duration T1D at several levels, including macrostructural, microstructural cerebral damage, and blood flow alterations. In this cross-sectional study, we compared a cohort of 61 patients with T1D with an average disease duration of 21 years with 54 well-matched control subjects without diabetes in a multimodal MRI protocol providing macrostructural metrics (cortical thickness and structural volumes), microstructural measures (T1-weighted/T2-weighted [T1w/T2w] ratio as a marker of myelin content, inflammation, and edema), and cerebral blood flow. Patients with T1D had higher T1w/T2w ratios in the right parahippocampal gyrus, the executive part of both putamina, both thalami, and the cerebellum. These alterations were reflected in lower putaminal and thalamic volume bilaterally. No cerebral blood flow differences between groups were found in any of these structures, suggesting nonvascular etiologies of these changes. Our findings implicate a marked nonvascular disruption in T1D of several essential neural nodes engaged in both cognitive and motor processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.