ArticleProceedings of the National Academy of Sciences of the United States of America2020
KMT5c modulates adipocyte thermogenesis by regulating
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Decoding the Adipocyte Epigenome: Differentiation, Metabolic Memory, and Obesity.Journal of obesity & metabolic syndrome · 2025Review
- Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner.Journal of translational medicine · 2025Article
- Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.The EMBO journal · 2025Article
- Cold-induced hepatocyte-derived exosomes activate brown adipose thermogenesis via miR-293-5p-mediated transcriptional reprogramming.Cell death discovery · 2025Article
- Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.Nature communications · 2025Article
- The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis.JCI insight · 2024Article
- Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis.International journal of oncology · 2024Article
- Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies.Signal transduction and targeted therapy · 2023Review
- Molecular and cellular regulation of thermogenic fat.Frontiers in endocrinology · 2023Review
- Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease.Frontiers in genetics · 2023Review
- The SUV4-20H Histone Methyltransferases in Health and Disease.International journal of molecular sciences · 2022Review
- Deconstructing Adipose Tissue Heterogeneity One Cell at a Time.Frontiers in endocrinology · 2022Review
- p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting.Frontiers in genetics · 2022Article
- Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.The EMBO journal · 2021Article
- Epigenetic regulation of energy metabolism in obesity.Journal of molecular cell biology · 2021Review
- Epigenetic Regulators of White Adipocyte Browning.Epigenomes · 2021Review
- Comparative Transcriptome Profiling of Cold Exposure and β3-AR Agonist CL316,243-Induced Browning of White Fat.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown and beige adipocytes harbor the thermogenic capacity to adapt to environmental thermal or nutritional changes. Histone methylation is an essential epigenetic modification involved in the modulation of nonshivering thermogenesis in adipocytes. Here, we describe a molecular network leading by KMT5c, a H4K20 methyltransferase, that regulates adipocyte thermogenesis and systemic energy expenditure. The expression of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.