Evidence map›Paper›PMID 32839292›Full record

ArticleMolecular and cellular biology2020

Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells.

Sarah B Lazar, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Bruna R Muys, Emily A Dangelmaier, Christophe E Redon, Sang-Min Jang, Robert L Walker, Wei Tang and 5 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  13. Drug Repurposing by Tumor Tissue Editing.Frontiers in oncology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Sarah B Lazar *Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Lorinc Pongor *Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda, Maryland, USA.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Bruna R MuysRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Emily A DangelmaierRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Christophe E RedonDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda, Maryland, USA.
Sang-Min JangDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda, Maryland, USA.
Robert L WalkerMolecular Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Wei TangMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA.
Stefan AmbsMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA.
Curtis C HarrisMolecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA.
Paul S MeltzerMolecular Genetics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Mirit I AladjemDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda, Maryland, USA.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA ashish.lal@nih.gov.ORCID 0000-0002-4299-8177
National Institutes of Health · USCenter for Cancer Research · USGenesis Laboratories · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiation status of tumors is correlated with metastatic potential and malignancy. FOXA1 (forkhead box A1) is a transcription factor known to regulate differentiation in certain tissues. Here, we investigate

Indexed as

Gene Regulatory NetworksAdenocarcinomaAnoikisCarcinoembryonic AntigenCell DifferentiationCell Line, TumorChromatin ImmunoprecipitationColorectal NeoplasmsEnhancer Elements, GeneticGene Expression Regulation, NeoplasticGenome-Wide Association StudyGPI-Linked ProteinsHepatocyte Nuclear Factor 3-alphaHigh-Throughput Nucleotide SequencingHumansProteinsCarcinoembryonic AntigenCEACAM5 protein, humanFOXA1 protein, humanGPI-Linked ProteinsHepatocyte Nuclear Factor 3-alphaProteinsRNA, Long Noncodingcell differentiationChIP-seqCRCFOXA1LINC00675lncRNARNA-seq

Identifiers

PMID32839292
PMCPMC7556848
OpenAlexW3080853679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.