Evidence map›Paper›PMID 32839188›Full record

ArticleInfection and immunity2020

Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin-Heat-Labile Toxin Chimera.

Aisling O'Dowd, Milton Maciel, Steven T Poole, Michael G Jobling, Julianne E Rollenhagen, Colleen M Woods, Stephanie A Sincock, Annette L McVeigh, Michael J Gregory, Ryan C Maves and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  2. Article
  3. Recent advances in enterotoxin vaccine adjuvants.Current opinion in immunology · 2023
    Review
  4. Article
  5. Evaluation of Multivalent EnterotoxigenicApplied and environmental microbiology · 2022
    Article
  6. Article
  7. Confronting challenges to enterotoxigenicFrontiers in tropical diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Aisling O'DowdHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Milton MacielHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA milton.maciel.ctr@mail.mil.ORCID 0000-0003-4877-9458
Steven T PooleHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Michael G JoblingDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Julianne E RollenhagenHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Colleen M WoodsEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Stephanie A SincockEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Annette L McVeighHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Michael J GregoryBacteriology Department, United States Naval Medical Research Unit No. 6, Lima, Peru.
Ryan C MavesDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Michael G ProutyEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Randall K HolmesDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Stephen J SavarinoEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Henry M. Jackson Foundation · USNaval Medical Research Command · USUniversity of Colorado Denver · USUnited States Naval Medical Research Unit SOUTH · PE

Funding

GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTIONR01AI031940 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLMES, RANDALL K · 1992 to 2011
$5.9M
Development of an Adhesin-Toxoid Chimera Vaccine for Enterotoxigenic E. coliU01AI070638 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SAVARINO, STEPHEN J · 2006 to 2010
$4.3M
NIAID NIH HHS R01 AI031940NIAID NIH HHS U01 AI070638
6 · The paper itself

Abstract

Recent efforts to develop an enterotoxigenic

Indexed as

Adhesins, Escherichia coliAnimalsAotidaeCholera ToxinEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli VaccinesGuinea PigsMiceRecombinant Fusion ProteinsAdhesins, Escherichia coliCholera ToxinEscherichia coli VaccinesRecombinant Fusion ProteinsCfaEchimerachimera LTBenterotoxigenic Escherichia coliETECguinea pigsH10407micenonhuman primatesvaccine

Identifiers

PMID32839188
PMCPMC7573451
OpenAlexW3080149860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.