Evidence map›Paper›PMID 32839181›Full record

ArticleDevelopment (Cambridge, England)2020

Positive autoregulation of

Katherine Leisan Luo, Ryan S Underwood, Iva Greenwald

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. SEM-2/SoxC regulates multiple aspects ofbioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katherine Leisan LuoIntegrated Program in Cellular, Molecular and Biophysical Studies, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-1509-5204
Ryan S UnderwoodDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-0538-494X
Iva GreenwaldDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-7180-3706
Columbia University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulatory Circuitry and Mechanisms Controlling Cell Fate in C. elegansR35GM131746 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Iva S Greenwald · 2019 to 2026
$5.0M
New modes and mechanisms of negative regulation of LIN-12/Notch in C. elegansR01GM114140 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENWALD, IVA S · 2015 to 2018
$1.4M
Spatial, temporal and environmental regulation of early gonadogenesis in C. elegansR01GM115718 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENWALD, IVA S · 2015 to 2018
$1.3M
Elucidation of Novel Post-Translational Mechanisms That Regulate Notch ActivityF31CA177168 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UNDERWOOD, RYAN SCOTT · 2013 to 2016
$169k
Characterizing LIN-12/Notch Regulation and ActivityF31CA236516 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUO, KATHERINE · 2018 to 2019
$85k
NCI NIH HHS F31 CA177168NCI NIH HHS F31 CA236516NIGMS NIH HHS R01 GM114140NIGMS NIH HHS R01 GM115718NIGMS NIH HHS R35 GM131746NIGMS NIH HHS T32 GM007367NIH HHS P40 OD010440
6 · The paper itself

Abstract

During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene transcription. We investigated the spatiotemporal regulation of LAG-1/CSL expression in

Indexed as

AnimalsBinding SitesCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsGene Expression RegulationGenitaliaHomeostasisReceptors, NotchSignal TransductionTranscription, GeneticUp-RegulationCaenorhabditis elegans ProteinsDNA-Binding ProteinsLAG-1 protein, C elegansLin-12 protein, C elegansReceptors, NotchAutoregulationC. elegansCSLEnhancerHOTlag-1Notch

Identifiers

PMID32839181
PMCPMC7541336
OpenAlexW3080753241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.