Evidence map›Paper›PMID 32839179›Full record

ArticleCold Spring Harbor molecular case studies2020

Diffuse midline glioma with novel, potentially targetable,

George Zanazzi, Benjamin L Liechty, Danielle Pendrick, Olga Krasnozhen-Ratush, Matija Snuderl, Jeffrey C Allen, James H Garvin, Mahesh M Mansukhani, Kevin A Roth, Susan J Hsiao

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pediatric low-grade brainstem glioma: a review of current diagnosis and treatment paradigms in the molecular era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

George ZanazziDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Benjamin L LiechtyDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Danielle PendrickDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Olga Krasnozhen-RatushDepartment of Pathology, NYU Langone Medical Center, New York, New York, 10016, USA.
Matija SnuderlDepartment of Pathology, NYU Langone Medical Center, New York, New York, 10016, USA.
Jeffrey C AllenDepartment of Pediatrics, NYU Langone Medical Center, New York, New York 10016, USA.ORCID 0000-0001-9957-6664
James H GarvinDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York 10032, USA.
Mahesh M MansukhaniDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Kevin A RothDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Susan J HsiaoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Columbia University Irving Medical Center · USNYU Langone Health · USBaystate Medical Center · USCornell University · USDartmouth–Hitchcock Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a slow-growing, diffuse, infiltrating glioma in the right brainstem of a 9-yr-old boy. The tumor was negative by immunohistochemical staining for histone H3 K27M, BRAF V600E, and IDH1 R132H mutations. Fluorescence in situ hybridization did not reveal a BRAF duplication. Genomic profiling of the tumor, by DNA methylation array and cancer whole-exome and transcriptome sequencing, was performed. This analysis showed copy-number alterations, including gains of several chromosomes. In addition, a novel fusion involving the first 17 exons of

Indexed as

Brain NeoplasmsChildExome SequencingGliomaHumansIn Situ Hybridization, FluorescenceMaleMutationReceptor, Fibroblast Growth Factor, Type 2Vesicular Transport ProteinsFGFR2 protein, humanReceptor, Fibroblast Growth Factor, Type 2Vesicular Transport ProteinsVPS35 protein, humanneoplasm of the central nervous system

Identifiers

PMID32839179
PMCPMC7552930
OpenAlexW3080386643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.