Evidence map›Paper›PMID 32839155›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2021

Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder.

Istvan Molnar-Szakacs, Lauren Kupis, Lucina Q Uddin

Abstract readReview
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Risk and Resilience in Extraordinary Times.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Istvan Molnar-SzakacsResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: imolnar@ucla.edu.
Lauren KupisDepartment of Psychology, University of Miami, Coral Gables, Florida.
Lucina Q UddinDepartment of Psychology, University of Miami, Coral Gables, Florida; Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: l.uddin@miami.edu.

Funding

Cognitive and Neural Flexibility in AutismR01MH107549 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI UDDIN, LUCINA QAZI · 2015 to 2019
$2.4M
Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
NICHD NIH HHS T32 HD091059NIMH NIH HHS R01 MH107549
6 · The paper itself

Abstract

Autism spectrum disorder is a complex, heterogeneous neurodevelopmental condition of largely unknown etiology. This heterogeneity of symptom presentation, combined with high rates of comorbidity with other developmental disorders and a lack of reliable biomarkers, makes diagnosing and evaluating life outcomes for individuals with autism spectrum disorder a challenge. We review the growing literature on neuroimaging-based biomarkers of risk for the development of autism and explore evidence for resilience in some autistic individuals. The current literature suggests that neuroimaging during early infancy, in combination with prebirth and early genetic studies, is a promising tool for identifying biomarkers of risk, while studies of gene expression and DNA methylation have provided some key insights into mechanisms of resilience. With genetics and the environment contributing to both risk for the development of autism spectrum disorder and conditions for resilience, additional studies are needed to understand how risk and resilience interact mechanistically, whereby factors of risk may engender conditions for adaptation. Future studies should prioritize longitudinal designs in global cohorts, with the involvement of the autism community as partners in research to help identify domains of functioning that hold value and importance to the community.

Indexed as

Autism Spectrum DisorderAutistic DisorderBiomarkersHumansNeuroimagingBiomarkersAutism communityBiomarkerEarly developmentEpigeneticHeterogeneityOXTR

Identifiers

PMID32839155
PMCPMC7785575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.