ArticleBMC pediatrics2020
Neutrophil-to-lymphocyte ratio and scoring system for predicting coronary artery lesions of Kawasaki disease.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Neutrophil to Lymphocyte Ratio as a Biomarker for Predicting the Coronary Artery Abnormality in Kawasaki Disease: A Meta-Analysis.Disease markers · 2022Pooled it
- Prognostic Role of the Neutrophil-to-Lymphocyte Ratio in Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Increased Risk of Asthma and Allergic Rhinitis in Patients With a Past History of Kawasaki Disease: A Systematic Review and Meta-Analyses.Frontiers in pediatrics · 2021Pooled it
- Interleukin-17A, Interleukin-8, and Platelet Count Are Associated With Baseline Coronary Artery Lesions in Children With Kawasaki Disease: A Retrospective Exploratory Cohort Study.Immunity, inflammation and disease · 2026Article
- Electrocardiographic Alterations Combined with Hematological, Biochemical, and Metabolic Profiles Predict Prognosis in Kawasaki Disease.Journal of cardiovascular development and disease · 2026Article
- Advance in the Kawasaki disease related coronary artery aneurysms: knowledge mapping, trends, and research frontiers.Journal of cardiothoracic surgery · 2026Review
- Predictive value of the lactate dehydrogenase to albumin ratio for coronary artery lesions and IVIG resistance in Kawasaki disease.BMC pediatrics · 2026Article
- Neutrophil heterogeneity in Kawasaki disease and multisystem inflammatory syndrome in children.Pediatric research · 2026Review
- Novel risk scoring system for predicting intravenous immunoglobulin resistance and coronary artery aneurysm in Thai children with Kawasaki disease.Pediatric rheumatology online journal · 2025Article
- METTL3-mediated mApplied biochemistry and biotechnology · 2025Article
- Development and validation of an early predictive model for coronary artery lesions in incomplete Kawasaki disease.Translational pediatrics · 2025Article
- Predictive value of the combined evaluation of the neutrophil-to-lymphocyte ratio and lactate dehydrogenase level for coronary artery lesions in patients with acute Kawasaki disease.Italian journal of pediatrics · 2025Article
- Correlation between peripheral blood Th17/Treg immune imbalance and coronary artery lesions in children with Kawasaki disease.BMC immunology · 2025Article
- Long-Term Outcomes of Coronary Artery Aneurysms in Children With Kawasaki Disease: A Systematic Review.Cureus · 2025Review
- [Value of monocyte-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in evaluating the severity and prognosis of pediatric viral encephalitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Differentiating Kawasaki Disease and Multisystem Inflammatory Syndrome in Children Using Blood Composite Scores: Insights into Clinical Outcomes and Predictive Indices.Pediatric cardiology · 2025Article
- Risk factors associated with persistent coronary artery lesions in children with Kawasaki disease in an Italian cohort.European journal of pediatrics · 2025Article
- A visualized nomogram to predict intravenous immunoglobulin resistance in Kawasaki disease: a study based on the population in Southern China.Italian journal of pediatrics · 2025Article
- Value of dynamic changes in inflammatory biomarkers for predicting intravenous immunoglobulin resistance in children with Kawasaki disease.Frontiers in immunology · 2025Article
- Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundKawasaki disease (KD) causes coronary artery lesions (CAL) and is the leading cause of acquired heart disease in children. The aim of this study is to evaluate the risk factors and set-up a scoring system for predicting CAL of KD.
methodsWe retrospectively reviewed a total of 478 patients diagnosed with KD. We compared age, gender, laboratory data, and treatment response in two groups and developed a scoring system for predicting CAL.
resultsDuring the study period, 365 of these patients had complete medical records of coronary surveys by echocardiography. Anemia, hypoalbuminemia, C reactive protein (CRP), alanine aminotransferase, neutrophil count, and neutrophil/lymphocyte ratio (NLR) showed significant differences with CAL formation. We determined the cut-off value using a receiver-operating-characteristic (ROC) curve, and following multivariate logistic regression analysis, four independent risk factors demonstrated a significant difference with CAL formation, including CRP > 103 mg/L, NLR > 3.5, male gender, and intravenous immunoglobulin (IVIG) resistance. We established a score system based on the above evaluation, for which a ROC curve was performed, and a total score of ≥ 2 points showed a sensitivity of 60.8% and a specificity of 70.6%, with an area under the ROC curve of 0.696.
conclusionsIdentifying children at risk is important in order to prevent CAL from developing. Four independent risk factors that can predict CAL formation were CRP > 103 mg/L, NLR > 3.5, male gender, and IVIG resistance. This first report incorporated NLR into score systems to predict CAL reinforces previously well-known risk factors for the CAL formation among KD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.