Evidence map›Paper›PMID 32838590›Full record

ArticleInhalation toxicology2020

A single exposure to eucalyptus smoke sensitizes rats to the postprandial cardiovascular effects of a high carbohydrate oral load.

Brandi L Martin, Leslie C Thompson, Yong Ho Kim, Samantha J Snow, Mette C Schladweiler, Pamela Phillips, Molly Harmon, Charly King, Judy Richards, Ingrid George and 6 more

Open access · greenAbstract read
In one paragraph

Article in Inhalation toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Brandi L MartinOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Leslie C ThompsonPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Yong Ho KimOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.ORCID 0000-0001-7527-0134
Samantha J SnowPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Mette C SchladweilerPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Pamela PhillipsPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Molly HarmonCurriculum of Toxicology and Environmental Medicine Division, UNC-Chapel Hill, Chapel Hill, NC, USA.
Charly KingPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Judy RichardsPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Ingrid GeorgeAir Methods & Characterization Division, US EPA, Research Triangle Park, NC, USA.
W Kyle MartinCurriculum of Toxicology and Environmental Medicine Division, UNC-Chapel Hill, Chapel Hill, NC, USA.
Najwa Haykal-CoatesPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
M Ian GilmourPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.ORCID 0000-0002-3070-6704
Urmila P KodavantiPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Mehdi S HazariPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Aimen K FarrajPublic Health and Integrated Toxicology Division, US EPA, Research Triangle Park, NC, USA.
Environmental Protection Agency · USOak Ridge Associated Universities · USUniversity of North Carolina at Chapel Hill · US

Funding

TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Intramural EPA EPA999999NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

objectivePrevious studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict cardiovascular risk, in assessing the impacts of exposure to eucalyptus smoke (ES), a contributor to wildland fire air pollution in the Western coast of the United States. MATERIALS AND

methodsThree-month-old male Sprague Dawley rats were exposed once (1 h) to filtered air (FA) or ES (700 µg/m

resultsES inhalation alone increased serum interleukin (IL)-4 and nasal airway levels of gamma glutamyl transferase. HC gavage alone increased blood glucose, blood pressure, and serum IL-6 and IL-13 compared to water vehicle. By contrast, only ES-exposed and HC-challenged animals had increased PV loop measures of cardiac output, ejection fraction %, d DISCUSSION AND

conclusionsExposure to a model wildfire air pollution source modifies cardiovascular responses to HC challenge, suggesting air pollution sensitizes the body to systemic triggers.

Indexed as

EucalyptusAdministration, InhalationAir PollutantsAnimalsBlood GlucoseBlood PressureBronchoalveolar Lavage FluidCardiac OutputCytokinesDietary CarbohydratesMaleNasal Lavage FluidPostprandial PeriodRats, Sprague-DawleySmokeStroke VolumeAir PollutantsBlood GlucoseCytokinesDietary CarbohydratesSmokeAir pollutioncardiovasculareucalyptus smokehigh carbohydrate mealinhalationpostprandialwildland fires

Identifiers

PMID32838590
PMCPMC8240093
OpenAlexW3080941709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.