Evidence map›Paper›PMID 32838285›Full record

ArticleBiosafety and health2020

Seroprevalence of Wenzhou virus in China.

Li Guo, Shasha Liu, Jingdong Song, Lianlian Han, Hu Zhang, Chao Wu, Conghui Wang, Hongli Zhou, Jianwei Wang

Open access · goldAbstract read
In one paragraph

Article in Biosafety and health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Li GuoNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Shasha LiuNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Jingdong SongNational Institute for Viral Disease Control and Prevention, China CDC, 102206, China.
Lianlian HanNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Hu ZhangNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Chao WuNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Conghui WangNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Hongli ZhouNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Jianwei WangNational Health Commission Key Laboratory of Systems Biology of Pathogens, and Christophe Merieux Laboratory, Institute of Pathogen Biology of Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNNational Institute for Viral Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wenzhou virus (WENV) was first identified in rodents and Asian house shrews in Wenzhou, Zhejiang Province, China. However, little is known about the prevalence of WENV infections in humans in China. To determine the threat that WENV may pose to humans, we determine the seroprevalence of WENV in healthy individuals in China in this study. Cross-reactivities of nucleoprotein (NP) were detected between Lymphocytic choriomeningitis virus (LCMV) and WENV using Western blot and ELISA assy. The prevalence of specific IgG antibodies against WENV NP was investigated in different age groups of 830 healthy individuals aged 0-70 years old in China using a competition ELISA assay. The results indicate that WENV and LCMV share cross-reactive epitopes between NPs. The total seroprevalence of WENV in healthy adults was 4.6%, with 3.6% (8/221) for individuals 15-44 years of age, 5.4% (17/317) for individuals 45-59 years of age, and 4.1% (4/98) for older adults over 60. The total seroprevalence of WENV in children under age 15 was 1.5%, with 2.9% (1/34) in children aged 2-5 years, and 2.2% in 5-14 years (2/91). The finding suggests that WENV or WENV-like virus may sporadically infect humans of China.

Indexed as

Competition ELISACross-reactivityCross-species transmissionSeroprevalenceWenzhou virus

Identifiers

PMID32838285
PMCPMC7361105
OpenAlexW3043804952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.