ReviewAmerican journal of obstetrics & gynecology MFM2020
Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019.
Review in American journal of obstetrics & gynecology MFM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- [Infection with SARS-CoV-2 in pregnancy. Update of Information and proposed care. CNGOF].Gynecologie, obstetrique, fertilite & senologie · 2020Guideline
- Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.The Australian & New Zealand journal of obstetrics & gynaecology · 2020Guideline
- Repurposing of colchicine: critical examination of clinical trials and scoping review.European journal of clinical pharmacology · 2026Article
- Investigation of Teratogenic Concerns in the Coronavirus Disease of 2019 Era.Birth defects research · 2026Article
- Role of antimalarials in lupus nephritis: a narrative review.Clinical rheumatology · 2025Review
- Two successful pregnancies -in patients taking Volanesorsen for familial chylomicronemia syndrome.JIMD reports · 2024Article
- Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19.Current stem cell research & therapy · 2024Review
- Evolution of National Guidelines on Medicines Used to Treat COVID-19 in Pregnancy in 2020-2022: A Scoping Review.Journal of clinical medicine · 2023Article
- Maternal antibiotic administration during gestation can affect the memory and brain structure in mouse offspring.Frontiers in cellular neuroscience · 2023Article
- The clinical characteristics of COVID-19 omicron variant infection in pregnant women and their neonates.Frontiers in medicine · 2023Article
- Article
- COVID-19 in pregnancy-what study designs can we use to assess the risk of congenital anomalies in relation to COVID-19 disease, treatment and vaccination?Paediatric and perinatal epidemiology · 2022Review
- Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats.EBioMedicine · 2022Article
- Efficacy of oseltamivir in the treatment of patients infected with Covid-19.Annals of medicine and surgery (2012) · 2022Article
- Does the Fetus Limit Antibiotic Treatment in Pregnant Patients with COVID-19?Antibiotics (Basel, Switzerland) · 2022Article
- Favipiravir exposure and pregnancy outcome of COVID-19 patients.European journal of obstetrics, gynecology, and reproductive biology · 2022Article
- COVID-19 AND UPPER LIMB ANOMALIES IN NEWBORNS: A REASON FOR CONCERN?Acta ortopedica brasileira · 2022Review
- Pregnancy and COVID-19: prevention, vaccination, therapy, and beyondTurkish journal of medical sciences · 2021Review
- Pharmacological Treatments against COVID-19 in Pregnant Women.Journal of clinical medicine · 2021Review
- Global birth defects app: An innovative tool for describing and coding congenital anomalies at birth in low resource settings.Birth defects research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. Although pregnant women are excluded from clinical trials, they will inevitably receive therapies whenever they seem effective in nonpregnant patients and even under compassionate use. Methods: We conducted a review of the literature on placental transfer and pregnancy safety data of drugs under current investigation for coronavirus disease 2019. Results: Regarding remdesivir, there are no data in pregnant women. Several other candidates already have safety data in pregnant women, because they are repurposed drugs already used for their established indications. Thus, they may be used in pregnancy, although their safety in the context of coronavirus disease 2019 may differ from conventional use. These include HIV protease inhibitors such as lopinavir/ritonavir that have low placental transfer, interferon that does not cross the placental barrier, and hydroxychloroquine or chloroquine that has high placental transfer. There are also pregnancy safety and placental transfer data for colchicine, steroids, oseltamivir, azithromycin, and some monoclonal antibodies. However, some drugs are strictly prohibited in pregnancy because of known teratogenicity (thalidomide) or fetal toxicities (renin-angiotensin system blockers). Other candidates including tocilizumab, other interleukin 6 inhibitors, umifenovir, and favipiravir have insufficient data on pregnancy outcomes. Conclusion: In life-threatening cases of coronavirus disease 2019, the potential risks of therapy to the fetus may be more than offset by the benefit of curing the mother. Although preclinical and placental transfer studies are required for a number of potential anti-severe acute respiratory syndrome coronavirus 2 drugs, several medications can already be used in pregnant women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.