Evidence map›Paper›PMID 32838240›Full record

ArticleEClinicalMedicine2020

Cerebral Micro-Structural Changes in COVID-19 Patients - An MRI-based 3-month Follow-up Study.

Yiping Lu, Xuanxuan Li, Daoying Geng, Nan Mei, Pu-Yeh Wu, Chu-Chung Huang, Tianye Jia, Yajing Zhao, Dongdong Wang, Anling Xiao and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05195099 (Effectiveness of a Physiotherapy Respiratory and Neurorehabilitation Treatment Protocol in Patients With COVID-19.), which is not on this map. Cited by 367 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 6 pooled it
40.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05195099 nacompletednot on this mapstarted 2022, after this paper: background citation

Effectiveness of a Physiotherapy Respiratory and Neurorehabilitation Treatment Protocol in Patients With COVID-19.

TypeinterventionalSponsorUniversidad Católica de ÁvilaRan2022 to 2022Enrolled200ConditionsCOVID-19 PandemicArmsrespiratory treatment
3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 6 syntheses or guidelines pooled it, 638 citations in OpenAlex.

  1. Pooled it
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  3. Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
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  7. Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeutics.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yiping LuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Xuanxuan LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Daoying GengDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Nan MeiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Pu-Yeh WuGE Healthcare, MR Research China, Beijing, China (P Wu).
Chu-Chung HuangInstitute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China (C Huang).
Tianye JiaInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, England (T Jia).
Yajing ZhaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Dongdong WangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Anling XiaoDepartment of Radiology, Fu Yang No.2 Hospital, Anhui, China (A Xiao).
Bo YinDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China (Y Lu, X Li, D Geng, N Mei, Y Zhao, D Wang, B Yin).
Fudan University · CNEast China Normal University · CNKing's College London · GBNingbo No. 2 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We aimed to identify the existence of potential brain micro-structural changes related to SARS-CoV-2.

methodsIn this prospective study, diffusion tensor imaging (DTI) and 3D high-resolution T1WI sequences were acquired in 60 recovered COVID-19 patients (56.67% male; age: 44.10 ± 16.00) and 39 age- and sex-matched non-COVID-19 controls (56.41% male; age: 45.88 ± 13.90). Registered fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were quantified for DTI, and an index score system was introduced. Regional volumes derived from Voxel-based Morphometry (VBM) and DTI metrics were compared using analysis of covariance (ANCOVA). Two sample t-test and Spearman correlation were conducted to assess the relationships among imaging indices, index scores and clinical information.

findingsIn this follow-up stage, neurological symptoms were presented in 55% COVID-19 patients. COVID-19 patients had statistically significantly higher bilateral gray matter volumes (GMV) in olfactory cortices, hippocampi, insulas, left Rolandic operculum, left Heschl's gyrus and right cingulate gyrus and a general decline of MD, AD, RD accompanied with an increase of FA in white matter, especially AD in the right CR, EC and SFF, and MD in SFF compared with non-COVID-19 volunteers (corrected

interpretationStudy findings revealed possible disruption to micro-structural and functional brain integrity in the recovery stages of COVID-19, suggesting the long-term consequences of SARS-CoV-2.

fundingShanghai Natural Science Foundation, Youth Program of National Natural Science Foundation of China, Shanghai Sailing Program, Shanghai Science and Technology Development, Shanghai Municipal Science and Technology Major Project and ZJ Lab.

Indexed as

3D-T1WI, 3 Dimensional T1-weighted ImagesAAL-3, Automated Anatomical Labelling Atlas-3ACE-2, Angiotensin Converting Enzyme-2AD, Axial DiffusivityCentral Nervous System DiseasesCNS, Central Nervous SystemCOVID-19COVID-19, Coronavirus DiseaseCR, Corona RadiataCSF, Cerebral Spinal FluidDICOM, Digital Imaging and Communications in MedicineDiffusion Tensor ImagingDTI, Diffusion Tensor ImagingEC, External CapsuleFA, Fractional AnisotropyFOV, Field of ViewGM, Gray MatterGMV, Gray Matter VolumeHIV, Human Immunodeficiency VirusHSV, Herpes Simplex VirusJEV, Japanese Encephalitis VirusLDH, Lactate DehydrogenaseMD, Mean DiffusivityMPRAGE, Magnetization Prepared Rapid Gradient EchoNeuroimagingOB, Olfactory BulbPCR, Polymerase Chain ReactionProspective studiesRD, Radial DiffusivitySARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus-2SARS-CoV, Severe Acute Respiratory Syndrome CoronavirusSFF, Superior Frontal-occipital FasciculusTBSS, Track-based Spatial StatisticsTE, Echo TimeTR, Repetition TimeUF, Uncinate FasciculusURTI, Upper Respiratory Tract InfectionVBM, Voxel-based MorphometryWBC, White Blood CellWHO, World Health OrganizationWMV, White Matter VolumeWM, White Matter

Identifiers

PMID32838240
PMCPMC7396952
OpenAlexW3046814626

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.