ArticleJGH open : an open access journal of gastroenterology and hepatology2020
Hepatic steatosis as an independent risk factor for severe disease in patients with COVID-19: A computed tomography study.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The eyes see what the mind seeks: a systematic review of abdominal imaging findings in patients with COVID-19.The British journal of radiology · 2021Pooled it
- Relationship between hepatic and pancreatic steatosis and the COVID-19 pneumonia total severity score and prognosis with an emphasis on prognostic strengthDiagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Article
- Hepatocellular liver injury in hospitalized patients affected by COVID-19: Presence of different risk factors at different time points.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2022Observational
- Post-COVID-19 Liver Injury: Comprehensive Imaging With Multiparametric Ultrasound.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- Investigation of comorbidities of COVID-19 patients with hepatosteatosis using latent class analysis.Frontiers in public health · 2022Article
- Computed tomography evaluation of pancreatic steatosis: correlation with COVID-19 prognosis.Future virology · 2022Article
- Role of hepatosteatosis in the prognosis of COVID 19 disease.Clinical imaging · 2021Article
- A case of secondary sclerosing cholangitis due to COVID-19.Clinical imaging · 2021Article
- Long-term effects of obesity on COVID-19 patients discharged from hospital.Immunity, inflammation and disease · 2021Article
- Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition.World journal of gastroenterology · 2021Review
- Remarkable gastrointestinal and liver manifestations of COVID-19: A clinical and radiologic overview.World journal of clinical cases · 2021Review
- COVID-19 and the liver: an adverse outcome pathway perspective.Toxicology · 2021Review
- Coronavirus disease 2019 severity in obesity: Metabolic dysfunction-associated fatty liver disease in the spotlight.World journal of gastroenterology · 2021Review
- Hepatic steatosis: a risk factor for increased COVID-19 prevalence and severity-a computed tomography study.Egyptian liver journal · 2021Article
- The Relationship of Liver and Pancreas Density With Chest Computed Tomography Score Progression and Laboratory Findings in Patients With COVID-19.Journal of computer assisted tomographyArticle
- Is Fatty Liver Associated with Increased Mortality and Morbidity in Coronavirus Disease 2019 (COVID-19) Pneumonia?Journal of clinical and experimental hepatologyArticle
- Multisystem Imaging Manifestations of COVID-19, Part 2: From Cardiac Complications to Pediatric Manifestations.Radiographics : a review publication of the Radiological Society of North America, IncArticle
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID-19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID-19 pneumonia. Methods: We included 213 patients with a positive real time polymerase chain reaction (RT-PCR) test and chest computed tomography (CT) from an out-hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO-RADs system (COVID-19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3-4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver-to-spleen ratio (CT Results: Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO-RADs 1 and 51.7% CO-RADs 2-5. Severe tomographic disease was present in 103 patients (48.4%), all CO-RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9 Conclusion: HS was independently associated with severe COVID pneumonia. The physiopathological explanation of this finding remains to be elucidated. CT
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