ArticleProceedings of the National Academy of Sciences of the United States of America1988
Neural and humoral factors separately regulate neuropeptide Y, enkephalin, and chromogranin A and B mRNA levels in rat adrenal medulla.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- Pooled it
- Role of the Adrenal Medulla in Hypoglycaemia-Associated Autonomic Failure-A Diabetic Perspective.Metabolites · 2024Review
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- PACAP signaling in stress: insights from the chromaffin cell.Pflugers Archiv : European journal of physiology · 2018Review
- What's New in Endocrinology: The Chromaffin Cell.Frontiers in endocrinology · 2018Review
- Redistribution of adrenomedullary nicotinic acetylcholine receptor subunits and the effect on circulating epinephrine levels in a murine model of acute asthma.International journal of molecular medicine · 2017Article
- Direct effects of recurrent hypoglycaemia on adrenal catecholamine release.Diabetes & vascular disease research · 2015Article
- Article
- NPY and stress 30 years later: the peripheral view.Cellular and molecular neurobiology · 2012Review
- Neuroprotection by endogenous and exogenous PACAP following stroke.Regulatory peptides · 2006Article
- A calcium-initiated signaling pathway propagated through calcineurin and cAMP response element-binding protein activates proenkephalin gene transcription after depolarization.Molecular pharmacology · 2003Article
- Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice.Molecular psychiatry · 2002Article
- Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons.Cellular and molecular neurobiology · 1998Review
- Analysis of exocytosis mutants indicates close coupling between regulated secretion and transcription activation in Tetrahymena.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Glucocorticoid activation of chromogranin A gene expression. Identification and characterization of a novel glucocorticoid response element.The Journal of clinical investigation · 1994Article
- The adrenal chromaffin granule: a model for large dense core vesicles of endocrine and nervous tissue.Journal of anatomy · 1993Review
- In situ hybridization: mRNA levels of secretogranin II, VGF and peptidylglycine alpha-amidating monooxygenase in brain of salt-loaded rats.Histochemistry · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of neurogenic versus humoral factors on mRNA levels of several secretory proteins of rat adrenal medulla was studied in vivo. Increased splanchnic nerve activity was generated (reflexly) with insulin treatment. Twenty-four hours after insulin injection, levels of mRNAs encoding neuropeptides (enkephalin and neuropeptide Y) were increased 6.5-fold, whereas those of mRNAs for the major secretory proteins (chromogranins A and B) were unchanged. Bilateral transection of the splanchnic nerves completely prevented this increase. Hypophysectomy decreased levels of chromogranin A mRNA to 32% of control, suggesting a dependence on hormones of the pituitary-adrenal axis. Treatment of hypophysectomized rats with dexamethasone restored chromogranin A mRNA to basal levels. Chromogranin B mRNA levels were not changed by either insulin treatment or hypophysectomy. These results demonstrate (i) that different classes of secretory proteins present in chromaffin granules are regulated by different mechanisms, (ii) that this regulation occurs at a pretranslational site, and (iii) that the relative concentration of secretory constituents of chromaffin granules may vary. The significance of an altered composition of secretory-granule constituents, which may be important in hypotension or stress, is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.