Evidence map›Paper›PMID 32837299›Full record

ArticleEuropean journal of organic chemistry2020

New Metal-Free Route towards Imidazole-Substituted Uridine.

Henri-Philippe Mattelaer, Anne-Sophie Van Hool, Flip de Jong, Mark Van der Auweraer, Luc Van Meervelt, Wim Dehaen, Piet Herdewijn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Henri-Philippe MattelaerRega Institute for Medical Science Medicinal Chemistry KULeuven Herestraat 49 3000 Leuven Belgium.ORCID 0000-0003-0043-2308
Anne-Sophie Van HoolRega Institute for Medical Science Medicinal Chemistry KULeuven Herestraat 49 3000 Leuven Belgium.ORCID 0000-0002-4712-9376
Flip de JongDepartment of Chemistry, Molecular Imaging and Photonics KULeuven Celestijnenlaan 200F 3001 Leuven Belgium.ORCID 0000-0002-3442-0316
Mark Van der AuweraerDepartment of Chemistry, Molecular Imaging and Photonics KULeuven Celestijnenlaan 200F 3001 Leuven Belgium.ORCID 0000-0002-9022-1696
Luc Van MeerveltDepartment of Chemistry, Biochemistry, Molecular and Structural Biology Section KULeuven Celestijnenlaan 200F 3001 Leuven Belgium.ORCID 0000-0003-2186-5209
Wim DehaenDepartment of Chemistry, Molecular Design and Synthesis Leuven Celestijnenlaan 200F 3001 Leuven Belgium.ORCID 0000-0002-9597-0629
Piet HerdewijnRega Institute for Medical Science Medicinal Chemistry KULeuven Herestraat 49 3000 Leuven Belgium.ORCID 0000-0003-3589-8503
KU Leuven · BERega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleosides with a bi(hetero)aryl nucleobase have unique potential applications as antiviral drugs and molecular probes. The need for transition metal catalysis to synthesize these nucleosides from pre-functionalized building blocks and the use of nucleobase protection groups results in expensive and tedious syntheses. Herein we report that 5-imidazolyl-uracil can be obtained by scalable Van Leusen imidazole synthesis and regioselectively introduced on ribose to obtain the desired nucleoside in a 5 step synthesis (total yield 55 %). The 5-imidazolyl moiety leads to improved fluorescence properties. The only side-product formed was characterized by 2D-NMR and X-ray crystallography and could be suppressed during synthesis in favor of the desired product.

Indexed as

FleximersFluorescent probesGreen chemistryNucleobasesNucleosides

Identifiers

PMID32837299
PMCPMC7283795
OpenAlexW3030418161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.