Evidence map›Paper›PMID 32835999›Full record

ArticleEuropean journal of oncology nursing : the official journal of European Oncology Nursing Society2020

Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy.

Inger Utne, Bruce A Cooper, Christine Ritchie, Melisa Wong, Laura B Dunn, Borghild Loyland, Ellen Karine Grov, Marilyn J Hammer, Steven M Paul, Jon D Levine and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of oncology nursing : the official journal of European Oncology Nursing Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Inger UtneDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Bruce A CooperSchool of Nursing, University of California, San Francisco, CA, USA.
Christine RitchieDivision of Palliative Care and Geriatric Medicine, Massachusetts General Hospital Morgan Institute, Boston, MA, USA.
Melisa WongSchool of Medicine, University of California, San Francisco, CA, USA.
Laura B DunnSchool of Medicine, Stanford University, Stanford, CA, USA.
Borghild LoylandDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Ellen Karine GrovDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Marilyn J HammerThe Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana Farber Cancer Institute, Boston, MA, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Kord M KoberSchool of Nursing, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA, USA. Electronic address: chris.miaskowski@ucsf.edu.
University of California, San Francisco · USOsloMet – Oslo Metropolitan University · NODana-Farber Cancer Institute · USMassachusetts General Hospital · USStanford University · USUniversity of Pittsburgh · US

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Advancing patient-centered decision making in older adults with lung cancer: Incorporating risk of functional decline into treatment discussionsK76AG064431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WONG, MELISA L · 2019 to 2023
$1.3M
NCI NIH HHS R01 CA134900NIA NIH HHS K76 AG064431
6 · The paper itself

Abstract

purposeOlder adults receiving cancer chemotherapy are at increased risk for decrements in physical (PF) and cognitive (CF) function.

objectivesStudy identified subgroups of patients with distinct PF and CF profiles; risk factors associated with subgroup membership; and impact of subgroup membership on quality of life (QOL).

methodsIn 366 older oncology patients, PF and CF were assessed using the Physical Component Summary (PCS) of the SF-12 and Attentional Function Index, respectively. Latent profile analysis was used to identify subgroups of older patients with distinct PF/CF profiles.

resultsThree distinct PF/CF profiles were identified (i.e., Very Low PF + Moderate CF (15.6%); Low PF + Low CF (39.3%), Normal PF + Normal CF (45.1%)). Compared to the both Normal class, patients in the other two classes had a lower functional status, a worse comorbidity profile, and were less likely to exercise on a regular basis. Compared to the Both Normal class, patients in the Both Low class were less likely to be married/partnered, more likely to live alone, less likely to be employed, and more likely to report depression and back pain. Compared to the other two classes, patients in the Both Low class had a lower annual household income and were receiving chemotherapy with a worse toxicity profile.

conclusionFirst study to use a person-centered analytic approach to identify subgroups of older adults with distinct PF/CF profiles. Fifty-five percent of the older adults had statistically significant and clinically meaningful decrements in both PF AND CF that had negative effects on all aspects of QOL.

Indexed as

ComorbidityAgedAged, 80 and overAntineoplastic AgentsCaliforniaCognitionFemaleHumansMaleMiddle AgedNeoplasmsPhysical EnduranceQuality of LifeRisk FactorsAntineoplastic AgentsCancerChemotherapyCognitive functionOlder adultPatient reported outcomesPhysical function

Identifiers

PMID32835999
PMCPMC7584738
OpenAlexW3047557274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.