ArticleMolecular plant2020
Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications.
Article in Molecular plant, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Zaxinone mimics boost growth and productivity of wheat under normal and low-nutrient regimes.BMC plant biology · 2026Article
- Characterization and Quantification of Strigolactones in Root Exudates.Methods in molecular biology (Clifton, N.J.) · 2026Article
- LYCOPENE β-CYCLASE overexpression improves growth, modulates hormone content, and affects rhizospheric interactions in tobacco and tomato roots.Plant cell reports · 2025Article
- Zaxinone Synthase overexpression modulates rice physiology and metabolism, enhancing nutrient uptake, growth and productivity.Plant, cell & environment · 2025Article
- Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3.Frontiers in plant science · 2025Article
- Effect of exogenous treatment with zaxinone and its mimics on rice root microbiota across different growth stages.Scientific reports · 2024Article
- Chromosome-scale pearl millet genomes reveal CLAMT1b as key determinant of strigolactone pattern and Striga susceptibility.Nature communications · 2024Article
- Does zaxinone counteract strigolactones in shaping rice architecture?Plant signaling & behavior · 2023Article
- Zaxinone mimics (MiZax) efficiently promote growth and production of potato and strawberry plants under desert climate conditions.Scientific reports · 2023Article
- Rice straw-derived smoke water promotes rice root growth under phosphorus deficiency by modulating oxidative stress and photosynthetic gene expression.Scientific reports · 2023Article
- New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research.Biomolecules · 2023Article
- ZAXINONE SYNTHASE 2 regulates growth and arbuscular mycorrhizal symbiosis in rice.Plant physiology · 2023Article
- Editorial: Specialized metabolites manipulating organismal behaviors and rhizospheric communications.Frontiers in plant science · 2023Article
- Zaxinone synthase controls arbuscular mycorrhizal colonization level in rice.The Plant journal : for cell and molecular biology · 2022Article
- Protocol for characterizing strigolactones released by plant roots.STAR protocols · 2022Article
- Article
- A New Formulation for Strigolactone Suicidal Germination Agents, towards SuccessfulPlants (Basel, Switzerland) · 2022Article
- Evaluation of the Biostimulant Activity of Zaxinone Mimics (MiZax) in Crop Plants.Frontiers in plant science · 2022Article
- Metabolomics of plant root exudates: From sample preparation to data analysis.Frontiers in plant science · 2022Review
- Multi-omics approaches explain the growth-promoting effect of the apocarotenoid growth regulator zaxinone in rice.Communications biology · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and development. In addition, zaxinone has a large application potential in agriculture, due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone (SL) production. However, zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and utilization. In this study, we developed easy-to-synthesize and highly efficient mimics of zaxinone (MiZax). We performed a structure-activity relationship study using a series of apocarotenoids distinguished from zaxinone by different structural features. Using the obtained results, we designed several phenyl-based compounds synthesized with a high-yield through a simple method. Activity tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant, promoting growth, and reducing SL content in roots and root exudates of wild-type plants. Moreover, these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions, and did not negatively impact mycorrhization. Taken together, MiZax are a promising tool for elucidating zaxinone biology and investigating rice development, and suitable candidates for combating Striga and increasing crop growth.
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