ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022
Depression and Anxiety Are Common Among Patients With Cirrhosis.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Global Prevalence of Anxiety in Gastroenterology and Hepatology Outpatients: A Systematic Review and Meta-Analysis.Current gastroenterology reports · 2025Pooled it
- Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study.BMJ open gastroenterology · 2025Trial
- Financial Burden of Hepatocellular Carcinoma Screening in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Trial
- Hepatocellular carcinoma surveillance may be associated with potential psychological harms in patients with cirrhosis.Hepatology (Baltimore, Md.) · 2024Trial
- Effects of Opioids, Benzodiazepines, Gabapentinoids, and Antidepressants on Fracture Risk in Alcohol-Related Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Chronic psychological stress disrupts liver homeostasis by dysregulating oxidative phosphorylation via the PI3K/AKT/FoxO3a axis.iScience · 2026Article
- MASLD Is Associated With Decreased General Health Perception, Quality of Life and Work Productivity in a Low Fibrosis Population.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Article
- Clinical subtypes of co-morbid insomnia and obstructive sleep apnea (COMISA): results of a cluster analysis.Respiratory research · 2026Article
- Article
- Treatment-related differences in quality of life and psychological distress among patients with hepatocellular carcinoma: A cross-sectional analysis.Palliative & supportive care · 2026Article
- Prevalence of anxiety, depression and associated risk factors in gastroenterology outpatients: a multicenter cross-sectional study.BMC gastroenterology · 2026Article
- Post-traumatic growth in liver cirrhosis patients: a cross-sectional study on the roles of psychological resilience and fear of progression based on the stress-coping theory.Frontiers in psychology · 2026Article
- Comorbid Depression Among US Adults With Elastography-Defined Advanced Chronic Liver Disease and Clinically Significant Portal Hypertension: National Health and Nutrition Examination Survey 2017-2023.Gastro hep advances · 2026Article
- Global prevalence and predictors of depression and anxiety in patients with liver cirrhosis: a systematic review and meta-analysis.Frontiers in epidemiology · 2026Review
- Thirst in End-Stage Liver Disease: From Symptom Disregard to a Multidisciplinary Clinical Pathway and Future Perspectives: A Narrative Review.Journal of multidisciplinary healthcare · 2026Review
- Navigating Chronic Pain in Patients with Cirrhosis: Unique Analgesic Considerations and Non-Pharmacologic Options.Current hepatology reports · 2026Review
- Article
- Review
- Gut feeling gone wrong: Tangled relationship between disorders of gut-brain interaction and liver disease.World journal of hepatology · 2025Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsDepression and anxiety can have negative effects on patients and are important to treat. There have been few studies of their prevalence among patients with cirrhosis. We aimed to characterize the prevalence and risk factors for depression and anxiety in a large multi-center cohort of patients with cirrhosis.
methodsWe conducted a telephone-based survey of patients with cirrhosis at 3 health systems in the United States (a tertiary-care referral center, a safety net system, and a Veterans hospital) from April through December 2018. Of 2871 patients approached, 1021 (35.6%) completed the survey. Depression and anxiety were assessed using the PHQ-9 (range 0-25) and STAI (range 20-80) instruments, with clinically significant values defined as PHQ-9 ≥15 and STAI ≥40. We performed multivariate logistic regression analysis to identify factors associated with significant depression and anxiety.
resultsThe median PHQ-9 score was 7 (25
conclusionsNearly 1 in 6 patients with cirrhosis have moderately severe to severe depression and nearly half have moderate-severe anxiety. Patients with cirrhosis should be evaluated for both of these disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.