ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2021
The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- A meta-analysis of randomized controlled trials evaluating the effectiveness of fecal microbiota transplantation for patients with irritable bowel syndrome.BMC gastroenterology · 2024Pooled it
- Positive psychological well-being and clinical characteristics in IBS: A systematic review.General hospital psychiatryPooled it
- A Randomized Waitlist-Controlled Trial of a Positive Psychology Intervention for Irritable Bowel Syndrome: The WISH Proof-of-Concept Trial.Neurogastroenterology and motility · 2025Trial
- The WISH 2.0 Intervention for Irritable Bowel Syndrome: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2026Article
- Impact of different stress paradigms on irritable bowel syndrome: Evidence from clinical and animal studies.The Journal of international medical research · 2026Review
- Kinetics of resilience with onset and remission of pediatric functional gastrointestinal disorders: A longitudinal study.iScience · 2026Article
- The mediating role of resilience in the relationship between cognitive flexibility and psychological well-being in patients with irritable bowel syndrome: a cross-sectional study.BMC gastroenterology · 2026Article
- Pathogenesis and therapeutic strategies for irritable bowel syndrome: an integrated perspective from dynamic balance theory of Chinese medicine.Frontiers in medicine · 2026Review
- The Gut-Brain Axis-From Science to Clinical Practice.Gastro hep advances · 2026Review
- Role of Sex, Anxiety, and Resilience in the Association Between Adverse Childhood Experiences and Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- Charting the Path: Psychological Factors and Diet Adherence in Adolescents With Celiac Disease.Cureus · 2024Article
- Resilience in Adult Coeliac Patients on a Gluten-Free Diet: A Cross-Sectional Multicentre Italian Study.Nutrients · 2024Article
- The mediating role of resilience between caregiver burden and hope among patients with inflammatory bowel disease.Nursing open · 2024Article
- Factors promoting and hindering resilience in youth with inflammatory bowel disease: A descriptive qualitative study.Nursing open · 2024Article
- Neural correlates of perceived and relative resilience in male and female patients with irritable bowel syndrome.Neurogastroenterology and motility · 2024Article
- Review
- Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management.Nature reviews. Gastroenterology & hepatology · 2023Review
- Irritable Bowel Syndrome and Resilience.Journal of clinical medicine · 2023Review
- Positive psychological well-being: A novel concept for improving symptoms, quality of life, and health behaviors in irritable bowel syndrome.Neurogastroenterology and motility · 2023Article
- Impact of Rome IV irritable bowel syndrome on work and activities of daily living.Alimentary pharmacology & therapeutics · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsResilience is the ability to adapt positively to stress and adversity. It is a potential therapeutic target as it is reduced in irritable bowel syndrome (IBS) compared to healthy controls and associated with worse symptom severity and poorer quality of life. The aim of this study was to examine if these findings are generalizable by comparing resilience between IBS versus the general population and other chronic gastrointestinal (GI) conditions.
methodsParticipants in the general population completed an online survey containing questionnaires measuring demographics, diagnosis of IBS and other GI conditions, symptom severity, psychological symptoms, resilience, and early adverse life events (EALs). IBS was defined as having a physician diagnosis of IBS and/or meeting Rome criteria without co-morbid GI disease. All others were included in the general population group. The chronic GI conditions group included those with inflammatory bowel disease, celiac disease and/or microscopic colitis.
resultsResilience was lower in IBS (n = 820) than the general population (n = 1026; p < 0.001) and associated with worse IBS symptom severity (p < 0.05). Global mental health affected resilience differently in IBS compared to the general population (all p's < 0.05). EALs were associated with decreased ability to bounce back from adversity in both IBS and the general population (p < 0.001). Resilience scores were similar in IBS and other chronic GI conditions that present with similar symptoms.
conclusionsResilience is lower compared to the general U.S. population but does not appear to be specific to IBS as it is comparable to other chronic GI conditions. Low resilience negatively affects symptom severity and mental health and thus, may serve as a novel therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.