Evidence map›Paper›PMID 32835770›Full record

ArticleAnnals of epidemiology2021

Psychotropic medication use during pregnancy and gestational age at delivery.

Miriam J Haviland, Yael I Nillni, Matthew P Fox, David A Savitz, Elizabeth E Hatch, Kenneth J Rothman, Michele R Hacker, Tanran R Wang, Lauren A Wise

Open access · greenAbstract read
In one paragraph

Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Miriam J HavilandDepartment of Epidemiology, Boston University School of Public Health, Boston, MA. Electronic address: mhavilan@bu.edu.
Yael I NillniDepartment of Psychiatry, Boston University School of Medicine, Boston, MA; National Center for PTSD, Women's Health Sciences Division at VA Boston Healthcare System, Boston, MA.
Matthew P FoxDepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
David A SavitzDepartment of Epidemiology, Brown University School of Public Health, Providence, RI.
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
Kenneth J RothmanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA; RTI International, Research Triangle Park, NC.
Michele R HackerDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Tanran R WangDepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
Boston University · USBeth Israel Deaconess Medical Center · USBrown University · USRTI International · US

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
PTSD-Related Neurobiological Mediators of Negative Pregnancy OutcomesK23HD087428 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NILLNI, YAEL I · 2017 to 2020
$616k
Feasibility of an internet-based study of time-to-pregnancy in the United StatesR21HD072326 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2013 to 2014
$337k
NICHD NIH HHS K23 HD087428NICHD NIH HHS R01 HD086742NICHD NIH HHS R21 HD072326
6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate the association between psychotropic medication use during pregnancy and gestational age at delivery, after adjusting for depressive symptom and perceived stress severity.

methodsWe analyzed data on singleton live births from 2914 female Pregnancy Study Online participants, aged 21 to 45, with a reported conception from 6/2013 to 6/2018. Women reported psychotropic medication use at 8 to 12 weeks' and ~32 weeks' gestation. We measured depressive symptoms using the Major Depressive Inventory and perceived stress using the 10-item Perceived Stress Scale. Data on gestational age at delivery were based on self-reports and/or birth certificates. We used restricted mean survival time models, stratifying by severity of depressive symptoms (Major Depression Inventory <25 vs. ≥25) and perceived stress (Perceived Stress Scale <20 vs. ≥20).

resultsTwo hundred and ten (7.2%) participants reported using psychotropic medications during pregnancy. Mean gestational age at delivery among women who never used psychotropic medications was 38.2 weeks (95% confidence interval: 37.7, 38.7), whereas it was 37.3 weeks (95% confidence interval: 36.7, 37.9) among women who used psychotropic medications during pregnancy. Results were similar across strata of depressive symptoms and perceived stress.

conclusionsOur data indicate that the association between psychotropic medication use and gestational age at delivery is not confounded by indication.

Indexed as

Gestational AgePsychotropic DrugsAdultBirth CertificatesFemaleHumansInfant, NewbornMiddle AgedPregnancySelf ReportYoung AdultPsychotropic DrugsDepressionGestational agePregnancyPsychological stressPsychotropic drugs

Identifiers

PMID32835770
PMCPMC7736493
OpenAlexW3081055708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.