Evidence map›Paper›PMID 32835600›Full record

ArticleVirulence2020

A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor.

Susan Welkos, Irma Blanco, Udoka Okaro, Jennifer Chua, David DeShazer

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Opsonization Improves Dual Proteomic Analysis ofJournal of proteome research · 2026
    Article
  2. Article
  3. Vaccines · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Susan WelkosBacteriology Division, United States Army Medical Research Institute of Infectious Diseases , Frederick, Maryland, USA.ORCID 0000-0002-7254-3480
Irma BlancoBacteriology Division, United States Army Medical Research Institute of Infectious Diseases , Frederick, Maryland, USA.
Udoka OkaroBacteriology Division, United States Army Medical Research Institute of Infectious Diseases , Frederick, Maryland, USA.ORCID 0000-0001-8762-5959
Jennifer ChuaBacteriology Division, United States Army Medical Research Institute of Infectious Diseases , Frederick, Maryland, USA.ORCID 0000-0001-8156-5174
David DeShazerBacteriology Division, United States Army Medical Research Institute of Infectious Diseases , Frederick, Maryland, USA.ORCID 0000-0003-1758-1238
United States Army Medical Research Institute of Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and uninfected host cells to form multinucleated giant cells. In this study, we utilized a proteomics approach to identify bacterial proteins produced inside RAW264.7 murine macrophages and host proteins produced in response to

Indexed as

AnimalsAntibodies, BacterialBacterial ProteinsBurkholderia pseudomalleiFemaleMacaca mulattaMacrophagesMelioidosisMiceMice, Inbred BALB CRAW 264.7 CellsVirulenceVirulence FactorsAntibodies, BacterialBacterial ProteinsVirulence FactorsDomain of unknown functionfacultative intracellular pathogenselect agent

Identifiers

PMID32835600
PMCPMC7549894
OpenAlexW3081238696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.