Evidence map›Paper›PMID 32835307›Full record

ArticlePatterns (New York, N.Y.)2020

Transitive Sequencing Medical Records for Mining Predictive and Interpretable Temporal Representations.

Hossein Estiri, Zachary H Strasser, Jeffery G Klann, Thomas H McCoy, Kavishwar B Wagholikar, Sebastien Vasey, Victor M Castro, MaryKate E Murphy, Shawn N Murphy

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. An objective framework for evaluating unrecognized bias in medical AI models predicting COVID-19 outcomes.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  5. LCTree-Based Approach for Mining Frequent Items in Real-Time.Computational intelligence and neuroscience · 2022
    Article
  6. Article
  7. High-throughput phenotyping with temporal sequences.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  8. Article
  9. Article
  10. Influential Usage of Big Data and Artificial Intelligence in Healthcare.Computational and mathematical methods in medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hossein EstiriLaboratory of Computer Science, Massachusetts General Hospital, Boston, MA 02144, USA.
Zachary H StrasserLaboratory of Computer Science, Massachusetts General Hospital, Boston, MA 02144, USA.
Jeffery G KlannLaboratory of Computer Science, Massachusetts General Hospital, Boston, MA 02144, USA.
Thomas H McCoyHarvard Medical School, Boston, MA 02115, USA.
Kavishwar B WagholikarLaboratory of Computer Science, Massachusetts General Hospital, Boston, MA 02144, USA.
Sebastien VaseyDepartment of Mathematics, Harvard University, Cambridge, MA 02138, USA.
Victor M CastroResearch Information Science and Computing, Mass General Brigham, Somerville, MA 02145, USA.
MaryKate E MurphyResearch Information Science and Computing, Mass General Brigham, Somerville, MA 02145, USA.
Shawn N MurphyLaboratory of Computer Science, Massachusetts General Hospital, Boston, MA 02144, USA.

Funding

RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics EraR01HG009174 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI ARONSON, SAMUEL JEFFREY, MACRAE, CALUM A. · 2016 to 2019
$2.9M
NHGRI NIH HHS R01 HG009174NLM NIH HHS T15 LM007092
6 · The paper itself

Abstract

Electronic health records (EHRs) contain important temporal information about the progression of disease and treatment outcomes. This paper proposes a transitive sequencing approach for constructing temporal representations from EHR observations for downstream machine learning. Using clinical data from a cohort of patients with congestive heart failure, we mined temporal representations by transitive sequencing of EHR medication and diagnosis records for classification and prediction tasks. We compared the classification and prediction performances of the transitive sequential representations (bag-of-sequences approach) with the conventional approach of using aggregated vectors of EHR data (aggregated vector representation) across different classifiers. We found that the transitive sequential representations are better phenotype "differentiators" and predictors than the "atemporal" EHR records. Our results also demonstrated that data representations obtained from transitive sequencing of EHR observations can present novel insights about the progression of the disease that are difficult to discern when clinical data are treated independently of the patient's history.

Indexed as

data representationdiagnosis predictiondimensionality reductiondisease trajectorieselectronic health recordsmachine learningphenotypingsequencingtemporal representations

Identifiers

PMID32835307
PMCPMC7301790

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.