Evidence map›Paper›PMID 32835135›Full record

ReviewHuman microbiome journal2020

Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications.

Saroj Khatiwada, Astha Subedi

Open access · hybridAbstract readReview
In one paragraph

Review in Human microbiome journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Gut distress and interventionFrontiers in public health · 2023
    Pooled it
  2. Article
  3. Review
  4. The Microbiota-Human Health Axis.Microorganisms · 2025
    Review
  5. Review
  6. Review
  7. Human microbiome in post-acute COVID-19 syndrome (PACS).Current research in microbial sciences · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
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  17. Review
  18. Article
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  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Saroj KhatiwadaSchool of Medical Sciences, UNSW Sydney, Australia.
Astha SubediMedicine ICU, Tribhuvan University Teaching Hospital, Nepal.
Nepal Medical College Teaching Hospital · NPTribhuvan University Teaching Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a rapidly emerging disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease begins as an infection of lungs, which is self-limiting in the majority of infections; however, some develop severe respiratory distress and organ failures. Lung microbiome, though neglected previously have received interest recently because of its association with several respiratory diseases and immunity. Lung microbiome can modify the risk and consequences of COVID-19 disease by activating an innate and adaptive immune response. In this review, we examine the current evidence on COVID-19 disease and lung microbiome, and how lung microbiome can affect SARS-CoV-2 infection and the outcomes of this disease. To date there is no direct evidence from human or animal studies on the role of lung microbiome in modifying COVID-19 disease; however, related studies support that microbiome can play an essential role in developing immunity against viral infections. Future studies need to be undertaken to find the relationship between lung microbiome and COVID-19 disease.

Indexed as

ACE2, Angiotensin converting enzymeARDS, Acute respiratory distress syndromeARF, Acute respiratory failureCOPD, Chronic obstructive pulmonary diseaseCoronavirus disease (COVID-19)COVID-19, Coronavirus disease 2019CRP, C reactive proteinIFN, InterferonImmunityInfectionLung microbiomePAMP, Pathogen associated molecular patternsPRR, Pattern recognition receptorrRNA, Ribosomal RNARSV, Respiratory syncytial virusSARS-CoV-2, Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)TLR, Toll like receptorTNF, Tumour necrosis factor

Identifiers

PMID32835135
PMCPMC7405772
OpenAlexW3047015287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.