ReviewObesity medicine2020
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
Review in Obesity medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The controversial effect of smoking and nicotine in SARS-CoV-2 infection.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Review
- Formation and activity of NLRP3 inflammasome and histopathological changes in the lung of corpses with COVID-19.Journal of molecular histology · 2022Article
- Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination.International immunopharmacology · 2022Review
- Implications of testicular ACE2 and the renin-angiotensin system for SARS-CoV-2 on testis function.Nature reviews. Urology · 2022Review
- Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine.Journal of clinical medicine · 2021Review
- The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19.Journal, genetic engineering & biotechnology · 2021Article
- Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.Journal of natural medicines · 2021Article
- Review
- Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients.Science progress · 2021Article
- PTSD as an Endothelial Disease: Insights From COVID-19.Frontiers in cellular neuroscience · 2021Review
- Impact of Smoking on Women During the Covid-19 Pandemic.Frontiers in medicine · 2021Review
- Single cell sequencing unraveling genetic basis of severe COVID19 in obesity.Obesity medicine · 2020Review
- The potential use of ABO blood group system for risk stratification of COVID-19.Medical hypotheses · 2020Article
- "Weighing" the risks and benefits - Thromboprophylaxis challenges in obese COVID-19 patients.Obesity medicine · 2020Article
- Is diabetes a real susceptibility for SARS-CoV-2 oral manifestation?Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
23 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furin, with its increased cellular activity; this might explain why these subgroups are at an increased risk of COVID-19 related complications and deaths. In contrast, smoking decreases cellular levels of Furin, this finding may be at the origin of the decreased severity of COVID-19 in smokers. Chinese herbal derived luteolin is suggested to be putative Furin inhibitor, with previous success against Dengue Fever. Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Consequently, the use of ion channel inhibitors, such as Calcium Channel blockers or Potassium Channel blockers, can prevent cellular transfection early in the course of the illness. Nicotine patches and Colchicine have also been suggested as potential therapies due to Furin mediated inhibition of COVID-19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.