Evidence map›Paper›PMID 32834709›Full record

ArticleRussian journal of bioorganic chemistry2020

5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses.

Y V Nikolayeva, E A Ulashchik, E V Chekerda, A V Galochkina, N A Slesarchuk, A A Chistov, T D Nikitin, V A Korshun, V V Shmanai, A V Ustinov and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Russian journal of bioorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Photosensitizing Antivirals.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Y V NikolayevaSmorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia.
E A UlashchikInstitute of Physical Organic Chemistry of the NAS Belarus, 220072 Minsk, Belarus.
E V ChekerdaSmorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia.
A V GalochkinaSmorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia.
N A SlesarchukShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
A A ChistovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
T D NikitinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
V A KorshunShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
V V ShmanaiInstitute of Physical Organic Chemistry of the NAS Belarus, 220072 Minsk, Belarus.
A V UstinovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
A A ShtroSmorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia.
Research Institute of Influenza · RUInstitute of Bioorganic Chemistry · RUInstitute of Physical and Organic Chemistry · BYNational Research University Higher School of Economics · RUGause Institute of New Antibiotics Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2'-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

Indexed as

antiviral activityinfluenza A virusnon-nucleoside derivativesnucleosidesperylenylethynyluracil compoundsrespiratory viruses

Identifiers

PMID32834709
PMCPMC7305479
OpenAlexW3036439214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.