Evidence map›Paper›PMID 32834527›Full record

ReviewNeurology, psychiatry, and brain research2020

Neurological manifestations of COVID-19 and other coronaviruses: A systematic review.

Alyne Oliveira Correia, Pedro Walisson Gomes Feitosa, Jorge Lucas de Sousa Moreira, Samuel Átila Rodrigues Nogueira, Ricardo Brandão Fonseca, Maria Elizabeth Pereira Nobre

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, psychiatry, and brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 9 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 9 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  13. SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway.Frontiers in molecular neuroscience · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Neurological Involvements in COVID-19: A hospital-based study.Iranian journal of child neurology · 2023
    Article
  20. Neuropathic pain in patients with post-COVID-19.Northern clinics of Istanbul · 2023
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alyne Oliveira CorreiaDepartment of Neurosurgery, Hospital Universitário, Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco, Brazil.
Pedro Walisson Gomes FeitosaFaculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.
Jorge Lucas de Sousa MoreiraFaculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.
Samuel Átila Rodrigues NogueiraFaculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.
Ricardo Brandão FonsecaDepartment of Neurosurgery, Hospital Universitário, Universidade Federal do Vale do São Francisco, Petrolina, Pernambuco, Brazil.
Maria Elizabeth Pereira NobreFaculty of Medicine, Universidade Federal do Cariri, Barbalha, Ceará, Brazil.
Universidade Federal do Cariri · BRUniversidade Federal do Vale do São Francisco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the main neurological manifestations related to coronavirus infection in humans. METHODOLOGY: A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: "coronavirus" or "Sars-CoV-2" or "COVID-19" and "neurologic manifestations" or "neurological symptoms" or "meningitis" or "encephalitis" or "encephalopathy," following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

resultsSeven studies were included. Neurological alterations after CoV infection may vary from 17.3% to 36.4% and, in the pediatric age range, encephalitis may be as frequent as respiratory disorders, affecting 11 % and 12 % of patients, respectively. The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. The main neurological alterations were headache (69; 16.8 %), dizziness (57, 13.9 %), altered consciousness (46; 11.2 %), vomiting (26; 6.3 %), epileptic crises (7; 1.7 %), neuralgia (5; 1.2 %), and ataxia (3; 0.7 %). The main presumed diagnoses were acute viral meningitis/encephalitis in 25 (6.1 %) patients, hypoxic encephalopathy in 23 (5.6 %) patients, acute cerebrovascular disease in 6 (1.4 %) patients, 1 (0.2 %) patient with possible acute disseminated encephalomyelitis, 1 (0.2 %) patient with acute necrotizing hemorrhagic encephalopathy, and 2 (1.4 %) patients with CoV related to Guillain-Barré syndrome.

conclusionCoronaviruses have important neurotropic potential and they cause neurological alterations that range from mild to severe. The main neurological manifestations found were headache, dizziness and altered consciousness.

Indexed as

ACE2, angiotensin converting enzyme 2ADEM, acute disseminated encephalomyelitisANHE, acute necrotizing hemorrhagic encephalopathyBBE, Bickerstaff’s encephalitisCoronavirusCoV, coronavirusCOVID-19COVID-19, coronavirus disease 2019DPP4, dipeptidil peptidase 4EncephalopathyGBS, Guillain-Barré syndromeG-CSF, granulocyte colony stimulating factor (G-CSF)GM-CSF, granulocyte-macrophage colony-stimulating factorHCoV-229E, Human coronavirus 229EHCoV, Human coronavirusHCoV-OC43, Human coronavirus OC43ICU, intensive care unitIL, interleukinMCP-1, monocyte chemoattractant protein-1MERS-CoV, Middle East respiratory syndrome coronavirusMERS, Middle East respiratory syndromeNeurologic manifestationsPRISMA, Preferred Reporting Items for Systematic Reviews and Meta-AnalysesSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2SARS‐CoV, severe acute respiratory syndrome coronavirusSARS, severe acute respiratory syndromeβCoV, betacoronavírus

Identifiers

PMID32834527
PMCPMC7261450
OpenAlexW3030230389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.