Evidence map›Paper›PMID 32833488›Full record

ArticleAnnals of internal medicine2020

Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study.

Eric J Chow, Melissa A Rolfes, Alissa O'Halloran, Evan J Anderson, Nancy M Bennett, Laurie Billing, Shua Chai, Elizabeth Dufort, Rachel Herlihy, Sue Kim and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 5 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 5 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 1 country.

Eric J ChowCenters for Disease Control and Prevention, Atlanta, Georgia (E.J.C., M.A.R., A.O., C.R., S.G.).ORCID 0000-0003-3349-9330
Melissa A RolfesCenters for Disease Control and Prevention, Atlanta, Georgia (E.J.C., M.A.R., A.O., C.R., S.G.).
Alissa O'HalloranCenters for Disease Control and Prevention, Atlanta, Georgia (E.J.C., M.A.R., A.O., C.R., S.G.).
Evan J AndersonEmory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, Georgia (E.J.A.).ORCID 0000-0002-1576-4420
Nancy M BennettUniversity of Rochester School of Medicine and Dentistry, Rochester, New York (N.M.B.).
Laurie BillingOhio Department of Health, Columbus, Ohio (L.B.).
Shua ChaiCenter for Preparedness and Response, Atlanta, Georgia (S.C.).ORCID 0000-0003-2048-2871
Elizabeth DufortNew York State Department of Health, Albany, New York (E.D.).
Rachel HerlihyColorado Department of Public Health and Environment, Denver, Colorado (R.H.).
Sue KimMichigan Department of Health and Human Services, Lansing, Michigan (S.K.).
Ruth LynfieldMinnesota Department of Health, St. Paul, Minnesota (R.L.).
Chelsea McMullenNew Mexico Department of Health, Santa Fe, New Mexico (C.M.).
Maya L MonroeMaryland Department of Health, Baltimore, Maryland (M.L.M.).
William SchaffnerVanderbilt University School of Medicine, Nashville, Tennessee (W.S., H.K.T.).
Melanie SpencerSalt Lake County Health Department, Salt Lake City, Utah (M.S.).
H Keipp TalbotVanderbilt University School of Medicine, Nashville, Tennessee (W.S., H.K.T.).
Ann ThomasOregon Public Health Division, Portland, Oregon (A.T.).
Kimberly Yousey-HindesYale School of Public Health, New Haven, Connecticut (K.Y.).ORCID 0000-0002-9418-575X
Carrie ReedCenters for Disease Control and Prevention, Atlanta, Georgia (E.J.C., M.A.R., A.O., C.R., S.G.).
Shikha GargCenters for Disease Control and Prevention, Atlanta, Georgia (E.J.C., M.A.R., A.O., C.R., S.G.).
Centers for Disease Control and Prevention · USVanderbilt University · USColorado Department of Public Health and Environment · USEmory University · USLake County · USMaryland Department of Health · USMichigan Department of Health and Human Services · USMinnesota Department of Health · USNew Mexico Department of Health · USNew York State Department of Health · USOffice of Readiness and Response · USOhio Department of Health · USOregon Health Authority · USUniversity of Rochester · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Intramural CDC HHS CC999999NCATS NIH HHS UL1 TR001863NCHM CDC HHS U38 HM000414OSTLTS CDC HHS U38 OT000143
6 · The paper itself

Abstract

backgroundInfluenza may contribute to the burden of acute cardiovascular events during annual influenza epidemics.

objectiveTo examine acute cardiovascular events and determine risk factors for acute heart failure (aHF) and acute ischemic heart disease (aIHD) in adults with a hospitalization associated with laboratory-confirmed influenza.

designCross-sectional study.

settingU.S. Influenza Hospitalization Surveillance Network during the 2010-to-2011 through 2017-to-2018 influenza seasons.

participantsAdults hospitalized with laboratory-confirmed influenza and identified through influenza testing ordered by a practitioner. MEASUREMENTS: Acute cardiovascular events were ascertained using discharge codes from the International Classification of Diseases (ICD), Ninth Revision, Clinical Modification, and ICD, 10th Revision. Age, sex, race/ethnicity, tobacco use, chronic conditions, influenza vaccination, influenza antiviral medication, and influenza type or subtype were included as exposures in logistic regression models, and marginal adjusted risk ratios and 95% CIs were estimated to describe factors associated with aHF or aIHD.

resultsAmong 89 999 adults with laboratory-confirmed influenza, 80 261 had complete medical record abstractions and available ICD codes (median age, 69 years [interquartile range, 54 to 81 years]) and 11.7% had an acute cardiovascular event. The most common such events (non-mutually exclusive) were aHF (6.2%) and aIHD (5.7%). Older age, tobacco use, underlying cardiovascular disease, diabetes, and renal disease were significantly associated with higher risk for aHF and aIHD in adults hospitalized with laboratory-confirmed influenza. LIMITATION: Underdetection of cases was likely because influenza testing was based on practitioner orders. Acute cardiovascular events were identified by ICD discharge codes and may be subject to misclassification bias.

conclusionIn this population-based study of adults hospitalized with influenza, almost 12% of patients had an acute cardiovascular event. Clinicians should ensure high rates of influenza vaccination, especially in those with underlying chronic conditions, to protect against acute cardiovascular events associated with influenza. PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention.

Indexed as

HospitalizationAcute DiseaseAgedAged, 80 and overAntiviral AgentsCross-Sectional StudiesHeart FailureHumansInfluenza, HumanInfluenza VaccinesLength of StayMiddle AgedMyocardial IschemiaRisk FactorsAntiviral AgentsInfluenza Vaccines

Identifiers

PMID32833488
PMCPMC8097760
OpenAlexW3081274660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.