Evidence map›Paper›PMID 32833276›Full record

ArticleAnnals of neurology2020

Autoantibodies Blocking M

Jose-Alberto Palma, Achla Gupta, Salvador Sierra, Ivone Gomes, Bhumika Balgobin, Lucy Norcliffe-Kaufmann, Lakshmi A Devi, Horacio Kaufmann

Open access · greenAbstract readCase Reports
In one paragraph

Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Muscarinic control of cardiovascular function in humans: a review of current clinical evidence.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Review
  4. Holiday heart syndrome: do not drink during this holiday! and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  5. Gastrointestinal motility disorders in neurologic disease.The Journal of clinical investigation · 2021
    Review
  6. Reflections on the past three decades of autonomic neurology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jose-Alberto Palma *Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-1345-6774
Achla Gupta *Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Salvador SierraDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ivone GomesDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Bhumika BalgobinDepartment of Neurology, Dysautonomia Center, New York University School of Medicine, New York, New York, USA.
Lucy Norcliffe-KaufmannDepartment of Neurology, Dysautonomia Center, New York University School of Medicine, New York, New York, USA.
Lakshmi A DeviDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Horacio KaufmannDepartment of Neurology, Dysautonomia Center, New York University School of Medicine, New York, New York, USA.
Dysautonomia Foundation · USIcahn School of Medicine at Mount Sinai · USSociety of Health and Physical Educators · USZero to Three · US

Funding

Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, ROY · 2009 to 2018
$11.6M
Enzymes Involved in Neuropeptide Biosynthesis, Processing and RegulationR01NS026880 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DEVI, LAKSHMI A · 1994 to 2019
$6.5M
Post-translational Regulation of Opioid and Cannabinoid Receptors.R37DA008863 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVI, LAKSHMI A · 2012 to 2021
$4.6M
NIDA NIH HHS R37 DA008863NINDS NIH HHS R01 NS026880NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

A 10-year-old girl presented with ileus, urinary retention, dry mouth, lack of tears, fixed dilated pupils, and diffuse anhidrosis 7 days after a febrile illness. We hypothesized that her syndrome was due to autoimmunity against muscarinic acetylcholine receptors, blocking their activation. Using an indirect enzyme-linked immunosorbent assay for all 5 muscarinic receptors (M

Indexed as

AutoantibodiesChildFemaleHumansPrimary DysautonomiasReceptor, Muscarinic M3AutoantibodiesReceptor, Muscarinic M3

Identifiers

PMID32833276
PMCPMC7674213
OpenAlexW3081333330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.