ArticleThe Prostate2020
Sleep quality and prostate cancer aggressiveness: Results from the REDUCE trial.
Article in The Prostate, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Sleep Duration and Prostate Cancer Risk in the Southern Community Cohort Study.Cancer medicine · 2026Article
- Sleep problems in prostate cancer patients: a comparison of several questionnaires measuring sleep quality.Frontiers in psychology · 2026Article
- Insomnia and prostate cancer risk: insights from NHANES and gene correlation analysis.Translational andrology and urology · 2025Article
- Insomnia in relation to 10 urological and reproductive conditions: a two-sample Mendelian randomization study.Translational andrology and urology · 2025Article
- Actigraphy-derived measures of sleep and risk of prostate cancer in the UK Biobank.Journal of the National Cancer Institute · 2024Article
- Poor sleep quality association with higher lung cancer risk: a nested case-control study.PeerJ · 2023Article
- Sleep and breast and prostate cancer risk in the MCC-Spain study.Scientific reports · 2022Article
- The relationship between sleep hygiene, mood, and insomnia symptoms in men with prostate cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients.Cancer metastasis reviews · 2021Review
- Integrative Approaches to Prostate Disease Management: Nutrition, Exercise, and Lifestyle Modifications.American journal of men's healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 4 countries.
Funding
Abstract
backgroundDisrupted sleep has been associated with increased risk of certain cancers. Little data exist in prostate cancer. We tested the association between sleep quality and prostate cancer diagnosis overall and by tumor grade in the Reduction by Dutasteride of Prostate Cancer Events chemoprevention trial. We hypothesized that worse sleep quality would be associated with increased tumor aggressiveness.
methodsAt baseline, 5614 men completed a validated six-item questionnaire on sleep quality. We generated a composite score categorized into tertiles to measure overall sleep quality and assessed each sleep quality question individually. Logistic regression was used to test associations between baseline sleep quality and overall, low-grade and high-grade prostate cancer diagnosis at 2-year study-mandated biopsy. Models were stratified by nocturia.
resultsOverall sleep quality was unrelated to overall or low-grade prostate cancer. Worse overall sleep quality was associated with elevated odds of high-grade prostate cancer (odds ratio [OR]
conclusionsOverall, associations between sleep quality and prostate cancer were inconsistent. However, there was some evidence for a positive association between insomnia and high-grade prostate cancer, and an inverse relationship between daytime sleepiness and low-grade prostate cancer; findings that should be validated by future studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.