Evidence map›Paper›PMID 32833137›Full record

ArticleInvestigational new drugs2021

Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro.

Martin Pola, Hana Kolarova, Jiri Ruzicka, Aleksey Zholobenko, Martin Modriansky, Jiri Mosinger, Robert Bajgar

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Cytotoxic Effects of Combinative ZnPcSInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin PolaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
Hana KolarovaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
Jiri RuzickaDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
Aleksey ZholobenkoDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
Martin ModrianskyDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
Jiri MosingerDepartment of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43, Prague 2, Czech Republic.
Robert BajgarDepartment of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. bajgar@tunw.upol.cz.ORCID 0000-0003-4854-4114
Palacký University Olomouc · CZCharles University · CZInstitute of Molecular and Translational Medicine · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is gradually becoming an alternative method in the treatment of several diseases. Here, we investigated the role of oxygen in photodynamically treated cervical cancer cells (HeLa). The effect of PDT on HeLa cells was assessed by exposing cultured cells to disulphonated zinc phthalocyanine (ZnPcS

Indexed as

Cell SurvivalDose-Response Relationship, DrugHeLa CellsHumansIndolesMembrane Potential, MitochondrialMetalloporphyrinsMitochondriaOrganometallic CompoundsOxygenPartial PressurePhotochemotherapyPhotosensitizing AgentsSinglet OxygenIndolesMetalloporphyrinsOrganometallic CompoundsOxygenPhotosensitizing AgentsSinglet Oxygenzinc phthalocyanine disulfonatezinc tetraphenylporphyrinHyperbariaPhotodynamic therapyPhotosensitizers

Identifiers

PMID32833137
OpenAlexW3081167620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.