Evidence map›Paper›PMID 32833090›Full record

ArticleEuropean radiology2021

Quantitative assessment of terminal ileum motility on MR enterography in Crohn disease: a feasibility study in children.

Lucia Cococcioni, Heather Fitzke, Alex Menys, Trevor Gaunt, Shankar Kumar, Fevronia Kiparissi, Dyanne Rampling, Liina Palm, Stuart A Taylor, Tom A Watson

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Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Practical applications of AI in body imaging.Abdominal radiology (New York) · 2026
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  9. Article
  10. Article
  11. Intestinal strictures in Crohn's disease: a 2021 update.Therapeutic advances in gastroenterology · 2022
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lucia CococcioniDepartment of Paediatric Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Heather FitzkeCentre for Medical Imaging, University College London, London, UK.
Alex MenysCentre for Medical Imaging, University College London, London, UK.
Trevor GauntDepartment of Paediatric Radiology, University College Hospital London, London, UK.
Shankar KumarCentre for Medical Imaging, University College London, London, UK.
Fevronia KiparissiDepartment of Paediatric Gastroenterology, Great Ormond Street Hospital for Children, London, UK.
Dyanne RamplingDepartment of Pathology, Great Ormond Street Hospital for Children, London, UK.
Liina PalmDepartment of Pathology, Great Ormond Street Hospital for Children, London, UK.
Stuart A TaylorCentre for Medical Imaging, University College London, London, UK.
Tom A WatsonDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, Wc1N 3JH, UK. Tom.Watson@gosh.nhs.uk.
University College London · GBGreat Ormond Street Hospital · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInvestigate the relationship between quantified terminal ileal (TI) motility and histopathological activity grading, Crohn Disease MRI Index (CDMI) and faecal calprotectin.

methodsRetrospective review of children with Crohn disease or unclassified inflammatory bowel disease, who underwent MR enterography. Dynamic imaging for 25 patients (median age 12, range 5 to 16) was analysed with a validated motility algorithm. The TI motility score was derived. The primary reference standard was TI Endoscopic biopsy Assessment of Inflammatory Activity (eAIS) within 40 days of the MR enterography. Secondary reference standards: (1) the Crohn Disease MRI Index (CDMI) and (2) faecal calprotectin levels.

resultsMR enterography median motility score was 0.17 a.u. (IQR 0.12 to 0.25; range 0.05 to 0.55), and median CDMI was 3 (IQR 0 to 5.5). Forty-three percent of patients had active disease (eAIS > 0) with a median eAIS score of 0 (IQR 0 to 2; range 0 to 5). The correlation between eAIS and motility was r = - 0.58 (p = 0.004, N = 23). Between CDMI and motility, r = - 0.42 (p = 0.037, N = 25). Motility score was lower in active disease (median 0.12 vs 0.21, p = 0.020) while CDMI was higher (median 5 vs 1, p = 0.04). In a subset of 12 patients with faecal calprotectin within 3 months of MR enterography, correlation with motility was r = - 0.27 (p = 0.4).

conclusionsQuantified terminal ileum motility decreases with increasing histopathological abnormality in children with Crohn disease, reproducing findings in adults. TI motility showed a negative correlation with an MRI activity score but not with faecal calprotectin levels. KEY POINTS: • It is feasible to perform MRI quantified bowel motility assessment in children using free-breathing techniques. • Bowel motility in children with Crohn disease decreases as the extent of intestinal inflammation increases. • Quantified intestinal motility may be a candidate biomarker for treatment efficacy in children with Crohn disease.

Indexed as

Crohn DiseaseAdultChildFeasibility StudiesHumansIleumMagnetic Resonance ImagingRetrospective StudiesCrohn diseaseFunctional magnetic resonance imagingPaediatric

Identifiers

PMID32833090
OpenAlexW3080195803

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.