ArticleNature cancer2020
α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer.
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Article in Nature cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
7.3field-weighted citation impact, top 1% of its field
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Who cites it
107 citing papers in PubMed, 163 citations in OpenAlex.
- Mitochondrial metabolite transporters at the crossroads of metabolic reprogramming, epigenetic regulation and therapeutic vulnerabilities in colorectal cancer.Molecular biology reports · 2026Review
- Circulating tumor DNA-based detection of molecular residual disease in isocitrate dehydrogenase-mutant cholangiocarcinoma for biomarker-guided therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- α-KG conformationally stabilizes nuclear GLUD1-SNAIL complex to fuel trans-endothelial migration in metastasis.Nature communications · 2026Article
- Lactate, Carbohydrate Restriction, and Cancer Metabolism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Review
- From metabolic node to smart building block: α-Ketoglutarate-empowered biomaterials for programmable cell fate.Materials today. Bio · 2026Review
- A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin.Science (New York, N.Y.) · 2026Article
- Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.Cell death and differentiation · 2026Article
- Reprogramming macrophage immunometabolism via glutamine antagonism potentiates colorectal cancer therapy in mice.Nature communications · 2026Article
- Histone methylation defines c-Jun/Sox2/Hif1α axis that controls stemness and tumor progression in squamous cell carcinoma.Nature communications · 2026Article
- The metabolic profiles of cancer stem cells.Stem cell research & therapy · 2026Review
- lncRNA AL445238.2‑USP4 axis regulates cell survival and stemness in colon cancer.International journal of oncology · 2026Article
- β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights.Clinical and experimental medicine · 2026Review
- Article
- Gut microbial metabolites in colorectal cancer: dual roles in tumorigenesis, immune crosstalk, and therapeutic innovation.Frontiers in cellular and infection microbiology · 2026Review
- Tumor metabolic plasticity in therapy resistance: from the Warburg effect to mitochondrial hijacking.Theranostics · 2026Review
- SLC6A14-mediated glutamine promotes SYTL4-CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer.Experimental & molecular medicine · 2025Article
- A niche-dependent redox rheostat regulates epithelial stem cell fate.Nature communications · 2025Article
- α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development.Blood · 2025Article
- Long Non-Coding RNAs Contribute to Glucose Starvation-Induced Dedifferentiation in Lung Adenocarcinoma.Biomolecules · 2025Article
- Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery.Journal of cell communication and signaling · 2025Review
47 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Thai Q TranDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-7559-0525
Eric A Hanse *Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1234-0198
Amber N Habowski *Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Haiqing LiDivision of Informatics, Department of Computational and Quantitative Medicine, Center of Informatics, Beckman Research Institute of City of Hope Cancer Center, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5583-2240
Mari B Ishak GabraDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Ying YangDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Xazmin H LowmanDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Amelia M OoiDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Shu Y LiaoDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Robert A EdwardsDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Marian L WatermanDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Mei KongDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA. meik1@uci.edu.ORCID http://orcid.org/0000-0001-8139-2349
University of California, Irvine · USCity of Hope · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MUniv.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9MShared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAN ETTEN, RICHARD A. · 2018 to 2022
$9.7MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MCancer Cell Adaption to Glutamine DeprivationR01CA183989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KONG, MEI · 2014 to 2019
$1.7MProtein Phosphatase Control of AMPK FunctionR01GM132142 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KONG, MEI · 2019 to 2023
$1.2MNCI NIH HHS P30 CA033572NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA183989NCI NIH HHS T32 CA009054NCI NIH HHS U54 CA217378NIGMS NIH HHS R01 GM132142
Abstract
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental glutamine restriction further augments Wnt signaling in APC mutant intestinal organoids to promote stemness and leads to adenocarcinoma formation
Indexed as
Colorectal NeoplasmsWnt Signaling PathwayGlutamineHumansKetoglutaric AcidsOrganoidsTumor MicroenvironmentGlutamineKetoglutaric Acidscancer metabolismcolon cancerepigeneticsglutamineWnt signaling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.