Evidence map›Paper›PMID 32832873›Full record

ArticleACS pharmacology & translational science2020

Modulation of Lymphocyte Potassium Channel K

Seow Theng Ong, Saumya Bajaj, Mark R Tanner, Shih Chieh Chang, Bankala Krishnarjuna, Xuan Rui Ng, Rodrigo A V Morales, Ming Wei Chen, Dahai Luo, Dharmeshkumar Patel and 23 more

Open access · bronzeAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 8 institutions in 3 countries.

Seow Theng OngLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Saumya BajajLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Mark R TannerDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States.
Shih Chieh ChangLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Bankala KrishnarjunaMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Xuan Rui NgLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Rodrigo A V MoralesMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Ming Wei ChenLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Dahai LuoLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Dharmeshkumar PatelSchool of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.
Sabina YasminSchool of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.
Jeremy Jun Heng NgLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Zhong ZhuangLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Hai M NguyenDepartment of Pharmacology, University of California, Davis, California 95616, United States.
Abbas El SahiliSchool of Biological Sciences, Nanyang Institute of Structural Biology, Experimental Medicine building, Singapore 636921.
Julien LescarSchool of Biological Sciences, Nanyang Institute of Structural Biology, Experimental Medicine building, Singapore 636921.
Rahul PatilCentre for Drug Candidate Optimisation, Monash University, Parkville, Victoria 3052, Australia.
Susan A CharmanCentre for Drug Candidate Optimisation, Monash University, Parkville, Victoria 3052, Australia.
Edward G RobinsSingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Julian L GoggiSingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Peng Wen TanSingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Pragalath SadasivamSingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Boominathan RamasamySingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Siddana V HartimathSingapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Vikas DhawanPeptides International, Inc., Louisville, Kentucky 40269, United States.
Janna BednenkoTetraGenetics Inc, Arlington, Massachusetts 02474, United States.
Paul ColussiTetraGenetics Inc, Arlington, Massachusetts 02474, United States.
Heike WulffDepartment of Pharmacology, University of California, Davis, California 95616, United States.
Michael W PenningtonPeptides International, Inc., Louisville, Kentucky 40269, United States.
Serdar KuyucakSchool of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.
Raymond S NortonMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Christine BeetonDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States.
K George ChandyLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.
Nanyang Technological University · SGAgency for Science, Technology and Research · SGMonash University · AUThe University of Sydney · AUBaylor College of Medicine · USPeptides International (United States) · USTetraGenetics (United States) · USUniversity of California, Davis · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Consortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0M
KOMP Phase II Mouse PhenotypingU54HG006364 · NHGRI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2011 to 2015
$16.3M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
Microglial K+ Channels in Ischemic StrokeR01NS100294 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WULFF, HEIKE · 2017 to 2020
$1.3M
NCI NIH HHS P30 CA125123NHGRI NIH HHS U54 HG006348NHGRI NIH HHS U54 HG006364NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS T32 HL007676NINDS NIH HHS R01 NS100294
6 · The paper itself

Abstract

We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable peptide, EgK5, that modulates voltage-gated K

Identifiers

PMID32832873
PMCPMC7432667
OpenAlexW3024688967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.