ArticleEnvironmental epidemiology (Philadelphia, Pa.)2020
Age and mitochondrial DNA copy number influence the association between outdoor temperature and cognitive function: Insights from the VA Normative Aging Study.
Article in Environmental epidemiology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Effects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis.Environment international · 2024Pooled it
- The effect of climate extremes on disability, depression, and cognitive decline in middle-aged and older Chinese adults under different healthy lifestyle.Journal of global health · 2025Observational
- New considerations for representing moisture in indoor thermal conditions: Associations between enthalpy, cognitive performance, and thermal sensations.Indoor environments · 2025Article
- Mitochondrial DNA copy number variation across three generations: a possible biomarker for assessing perinatal outcomes.Human genomics · 2023Article
- Association between plasma L-carnitine levels and mitochondrial DNA copy number.BMC molecular and cell biology · 2023Article
- Ambient temperatures associated with reduced cognitive function in older adults in China.Scientific reports · 2023Article
- A State-of-the-Science Review on High-Resolution Metabolomics Application in Air Pollution Health Research: Current Progress, Analytical Challenges, and Recommendations for Future Direction.Environmental health perspectives · 2023Review
- The Associations of Meteorological and Environmental Factors with Memory Function of the Older Age in Urban Areas.International journal of environmental research and public health · 2022Article
- Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage.International journal of environmental research and public health · 2021Article
- Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD).International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGeneral cognitive function deteriorates with aging, a change that has been linked to outdoor temperature. Older individuals have reduced ability to adapt to changes in outdoor temperature than younger people. However, to what extent short-term changes in outdoor temperature interact with mitochondria to affect cognition in older people has not yet been determined.
methodsOur study included 591 participants of the Normative Aging Study who underwent multiple examinations between 2000 and 2013. Cognitive function was evaluated via the Mini-Mental State Examination. Outdoor temperature was estimated at residential addresses 1 day before the examination using on a validated spatiotemporal temperature model. Mitochondrial DNA copy number (mtDNAcn) was determined using buffy coat samples.
resultsWe found an interaction between temperature, age, mtDNAcn, and cognition. In individuals 84 years of age or older, cooler temperature was associated with low cognition (odds ratio = 1.2; 95% confidence interval = 1.05, 1.35 for a 1°C decrease in temperature;
conclusionsOur findings, albeit potentially underpowered, suggest that older individuals may be more susceptible to the influence of short-term temperature exposure on cognition. Moreover, the level of mtDNAcn may also modify the association between temperature and cognitive function, indicating a possible role of these cellular elements in this relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.