ArticleScience advances2020
IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression.
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In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
What it found
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Diet Quality and Risk of SARS-CoV-2 Infection or COVID-19: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial.Journal of cosmetic dermatology · 2025Trial
- Dengue and aging: challenges and opportunities in prevention and care. A narrative review.Emerging microbes & infections · 2026Review
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Non-canonical NF-κB drives a fate switch from germinal center to early effector B cells.iScience · 2026Article
- Article
- Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.bioRxiv : the preprint server for biology · 2026Article
- The role of IL-10 in antiviral immune memory development.ImmunoHorizons · 2026Review
- Multimodal analysis definesbioRxiv : the preprint server for biology · 2025Article
- Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection.Immunity & ageing : I & A · 2025Article
- Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank.bioRxiv : the preprint server for biology · 2025Article
- Lymphoma accelerates T cell and tissue aging.Cancer cell · 2025Article
- Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination.NPJ vaccines · 2025Article
- Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells.Blood research · 2025Article
- Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.Proceedings. Biological sciences · 2025Article
- Germinal center immune dynamics: challenges for effective vaccination in the elderly.Immunotherapy · 2025Review
- IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues.JCI insight · 2025Article
- Short-term high-fat diet impacts bone material properties and metabolism for adult and aged C57BL/6JN mice.Communications biology · 2025Article
- The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation.JCI insight · 2025Article
- Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration.Aging and disease · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Maha AlmananDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-9848-0027
Jana RaynorDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ireti OgunsulireDivision of Infection Immunology, Research Center Borstel, Borstel, Germany.
Anna MalyshkinaDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0001-5199-5472
Shibabrata MukherjeeDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Sarah A HummelDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jennifer T IngramDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ankur SainiDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-3963-6586
Markus M XieDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-1350-7364
Theresa AlenghatDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-4514-3710
Sing Sing WayCenter for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.ORCID 0000-0001-8948-1952
George S DeepeDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0001-6158-6461
Senad DivanovicDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0001-7538-0499
Harinder SinghDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-6330-8526
Emily MiraldiDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-0232-3116
Allan J ZajacDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Alexander L DentDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7226-8936
Christoph HölscherDivision of Infection Immunology, Research Center Borstel, Borstel, Germany.
Claire ChougnetDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
David A HildemanDivision of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-0421-8483
Cincinnati Children's Hospital Medical Center · USResearch Center Borstel - Leibniz Lung Center · DEUniversity of Alabama at Birmingham · USUniversity of Cincinnati Medical Center · USIndiana University School of Medicine
Funding
Immunopathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK099222 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic · 2013 to 2026
$5.6MRegulation of T Cell Activity During Chronic InfectionsR01AI049360 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZAJAC, ALLAN J · 2001 to 2019
$4.1MHost integration of commensal and pathogenic bacterial-derived signalsR01DK116868 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2018 to 2026
$4.1MMetabolic alterations in age-associated dendritic cell dysfunctionR01AG053498 · NIA · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A., HILDEMAN, DAVID A · 2017 to 2021
$2.9MThe control of allergic immune responses by follicular regulatory T cellsR01AI132771 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI DENT, ALEXANDER L · 2017 to 2021
$2.7MEpigenomic control of antimicrobial immunity in the intestineR01DK114123 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ALENGHAT, THERESA · 2018 to 2022
$1.8MPathogenesis and therapeutic targeting of immune disordersT32AI118697 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2016 to 2020
$683kHomeostasis and function of regulatory T cells in agingR56AG033057 · NIA · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A., HILDEMAN, DAVID A · 2019 to 2019
$643kNIAID NIH HHS R01 AI049360NIAID NIH HHS R01 AI132771NIAID NIH HHS T32 AI118697NIA NIH HHS R01 AG053498NIA NIH HHS R56 AG033057NIDDK NIH HHS R01 DK099222NIDDK NIH HHS R01 DK114123NIDDK NIH HHS R01 DK116868
Abstract
Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to irreversible defects in the immune system. In addition to increased interleukin-6 (IL-6), we found aged mice exhibit increased systemic IL-10 that requires forkhead box P3-negative (FoxP3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.