ArticleScience advances2020
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 2 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Exosome-Based Therapies for Alopecia Areata: A Systematic Review of Clinical and Experimental Evidence.International journal of molecular sciences · 2025Pooled it
- Full-Spectrum phototherapy in hair loss management: a systematic review of wavelength-dependent mechanisms, clinical efficacy, and future directions.Lasers in medical science · 2025Pooled it
- Citrus limon-Derived Extracellular Vesicles Promote Hair Growth.Applied biochemistry and biotechnology · 2026Article
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Iron Deficiency-Induced Hair Loss Is Associated with ROS-Mediated Disruption of Wnt/β-Catenin Signaling.Nutrients · 2026Article
- Article
- Microneedle technology integrated with diverse therapeutic modalities for hair regrowth in alopecia.Acta pharmaceutica Sinica. B · 2026Review
- Exosomal miRNA-218-5p derived from low-passage dermal papilla cells modulates hair follicle growth and development.Non-coding RNA research · 2026Article
- Targeting Endogenous Wnt Antagonists for Therapy Development in AGA: a Focus on DKKs and sFRPs.Stem cell reviews and reports · 2026Review
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2-ARE Pathway in C57BL/6J Mice.Journal of cosmetic dermatology · 2026Article
- Bio-Nanovesicle-Based Approaches for Hair and Skin Regeneration: An Updated Concise Review.Cells · 2026Review
- Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits.Biomolecules · 2026Review
- Exosomes in trichology: A literature review.JPRAS open · 2026Review
- Amine-Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation.Advanced healthcare materials · 2026Article
- Integrated multiomics analysis reveals the molecular features and crucial regulators of hair follicles in yak (Bos grunniens).Communications biology · 2026Article
- Progress in the Application of Exosomes in Androgenetic Alopecia: Focusing on Molecular Mechanisms.International journal of nanomedicine · 2026Review
- Hair follicle organoids: advances in construction, applications, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- Extracellular vesicles in atopic dermatitis: unraveling pathogenic mediators and engineering therapeutic vectors.Frontiers in immunology · 2026Review
- A Comprehensive Bibliometric Analysis of Global Research Trends in Hair Loss Treatment: Key Contributions, Emerging Hotspots, and Future Directions.Aesthetic surgery journal. Open forum · 2026Article
- Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway.Frontiers in cell and developmental biology · 2026Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid-derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid-derived exosomes up-regulated β-catenin, promoting the development of hair follicles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.