ArticleScience advances2020
Preserved visual memory and relational cognition performance in monkeys with selective hippocampal lesions.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Is memory spared in monkeys with selective lesions of the hippocampus?Behavioral neuroscience · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cost-effective, open-source, automated apparatus for testing transitive inference in mice.Scientific reports · 2026Article
- Effects of temporal lobe seizures on visual recognition memory in a non-human primate model.Epilepsy & behavior : E&B · 2025Article
- Centering cognitive neuroscience on task demands and generalization.Nature neuroscience · 2024Review
- What does preferential viewing tell us about the neurobiology of recognition memory?Trends in neurosciences · 2024Article
- Hippocampal lesions impair non-navigational spatial memory in macaques.Hippocampus · 2024Article
- A mathematical theory of relational generalization in transitive inference.bioRxiv : the preprint server for biology · 2024Article
- Inferior parietal cortex represents relational structures for explicit transitive inference.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Learning of object-in-context sequences in freely-moving macaques.bioRxiv : the preprint server for biology · 2023Article
- The amygdala is not necessary for the familiarity aspect of recognition memory.Nature communications · 2023Article
- Large-scale network dynamics underlying the first few hundred milliseconds after stimulus presentation: An investigation of visual recognition memory using iEEG.Human brain mapping · 2023Article
- Differential involvement of the anterior and posterior hippocampus, parahippocampus, and retrosplenial cortex in making precise judgments of spatial distance and object size for remotely acquired memories of environments and objects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Are there disciplinary boundaries in the comparative study of primate cognition?Current research in neurobiology · 2023Review
- Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.Nature communications · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity.BMC ophthalmology · 2021Article
- Adult neurogenesis alters response to an aversive distractor in a labyrinth maze without affecting spatial learning or memory.Hippocampus · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The theory that the hippocampus is critical for visual memory and relational cognition has been challenged by discovery of more spared hippocampal tissue than previously reported in H.M., previously unreported extra-hippocampal damage in developmental amnesiacs, and findings that the hippocampus is unnecessary for object-in-context memory in monkeys. These challenges highlight the need for causal tests of hippocampal function in nonhuman primate models. Here, we tested rhesus monkeys on a battery of cognitive tasks including transitive inference, temporal order memory, shape recall, source memory, and image recognition. Contrary to predictions, we observed no robust impairments in memory or relational cognition either within- or between-groups following hippocampal damage. These results caution against over-generalizing from human correlational studies or rodent experimental studies, compel a new generation of nonhuman primate studies, and indicate that we should reassess the relative contributions of the hippocampus proper compared to other regions in visual memory and relational cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.