Evidence map›Paper›PMID 32832587›Full record

ArticleJournal of nutrition & intermediary metabolism2019

Adiposity does not modify the effect of the dietary inflammatory potential on type 2 diabetes incidence among a prospective cohort of men.

Mark A Guinter, Anwar T Merchant, Fred K Tabung, Michael D Wirth, Nitin Shivappa, Thomas G Hurley, James R Hebert, Xuemei Sui, Steven N Blair, Susan E Steck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nutrition & intermediary metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Dietary Inflammatory Index in relation to Type 2 Diabetes: A Meta-Analysis.International journal of clinical practice · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mark A GuinterBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Anwar T MerchantDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Fred K TabungDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
Michael D WirthDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Nitin ShivappaDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Thomas G HurleyCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
James R HebertDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Xuemei SuiDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA.
Steven N BlairDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Susan E SteckDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
University of South Carolina · USAmerican Cancer Society · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
Impact of Physical Fitness and Exercise on HealthR37AG006945 · NIA · COOPER INSTITUTE · PI BLAIR, STEVEN N. · 2002 to 2005
$2.7M
CORONARY ARTERY CALCIUM, EXERCISE TESTS, AND CHD OUTCOMER01HL062508 · NHLBI · COOPER INSTITUTE · PI LAMONTE, MICHAEL J · 1999 to 2004
$2.5M
Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
IMPACT OF PHYSICAL FITNESS &EXERCISE ON HEALTHR01AG006945 · NIA · COOPER INSTITUTE · PI BLAIR, STEVEN N. · 1986 to 2001
$1.1M
Understanding Patterns of Change in Obesity and Physical Activity in AdultsR21DK088195 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SUI, XUEMEI · 2010 to 2011
$397k
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
NCI NIH HHS K99 CA207736NHLBI NIH HHS R01 HL062508NIA NIH HHS R01 AG006945NIA NIH HHS R37 AG006945NIDDK NIH HHS R21 DK088195NIDDK NIH HHS R44 DK103377NIGMS NIH HHS T32 GM081740
6 · The paper itself

Abstract

purposeInflammatory contributions from diet and adiposity may interact with respect to the development of type 2 diabetes mellitus (T2DM). We investigated the degree to which adiposity modified the association between dietary inflammatory potential and incident T2DM.

methodsData from 6,016 US men in the Aerobics Center Longitudinal Study who completed a 3-day diet record were used. The inflammatory potential of diet was characterized by the Dietary Inflammatory Index (DII®), and adiposity was assessed with body mass index, waist circumference, body fat percentage (BF) and waist-to-height ratio. Inverse probability weights were used in modified Poisson regression models to examine whether adiposity modifies the relationship between the DII and T2DM, while accounting for selection bias from participants who were lost to follow-up.

resultsThere were 336 incident cases of T2DM after a mean follow-up of 6.5 years. DII scores were not significantly associated with T2DM incidence in multivariable models, but point estimates were consistently elevated across increasing DII quartiles compared to the most anti-inflammatory DII quartile. In the model that evaluated BF, the term for overall effect modification was significant (p = 0.02), but there was no evidence of effect modification on the multiplicative and additive scales when examined further. Effect modification was not present for any other adiposity measures.

conclusionsWe did not observe evidence that a pro-inflammatory diet, as measured by the DII, is associated with incidence of T2DM, nor evidence that adiposity modifies a potential relationship. Further investigation is needed in larger cohorts with longer follow-up.

Indexed as

AdiposityDietary patternEffect modificationEpidemiologyInflammationObesity

Identifiers

PMID32832587
PMCPMC7440686
OpenAlexW2919470332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.