Trial reportBioMed research international2020
Valuable Role of Neutrophil CD64 and Highly Sensitive CRP Biomarkers for Diagnostic, Monitoring, and Prognostic Evaluations of Sepsis Patients in Neonatal ICUs.
Trial report in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A meta-analysis of the association between inflammatory cytokine polymorphism and neonatal sepsis.PloS one · 2024Pooled it
- Diagnostic utility of neutrophil CD64 for early detection of neonatal sepsis in southwestern Nigeria: a comparative case-control study.BMC pediatrics · 2026Article
- The Role of Neutrophil CD11b Compared to Neutrophil CD64 as an Early Diagnostic, Monitoring, and Prognostic Sepsis Marker in Neonatal ICUs: Case-Control-Methodological Study.BioMed research international · 2025Article
- Evaluation of whole blood CD64 for identifying infection in neonates receiving hospital care.Frontiers in immunology · 2025Article
- Review
- Neutrophil CD64-a prognostic marker of sepsis in intensive care unit: a prospective cohort study.Frontiers in medicine · 2023Article
- Article
- Neutrophil CD64 index for diagnosis of infectious disease in the pediatric ICU: a single-center prospective study.BMC pediatrics · 2022Observational
- Biomarkers for the Prediction and Judgement of Sepsis and Sepsis Complications: A Step towardsJournal of clinical medicine · 2022Review
- Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers.Frontiers in pediatrics · 2022Review
- Clinical application value of serum neutrophil gelatinase-associated lipocalin in neonatal sepsis.Translational pediatrics · 2022Article
- Diagnostic, Prognostic, Predictive, and Monitoring Role of Neutrophil CD11b and Monocyte CD14 in Neonatal Sepsis.Disease markers · 2021Article
- The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis.International journal of microbiology · 2020Article
- High expression of neutrophil and monocyte CD64 with simultaneous lack of upregulation of adhesion receptors CD11b, CD162, CD15, CD65 on neutrophils in severe COVID-19.Therapeutic advances in infectious diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal sepsis (NS) is a very critical medical situation associated with high morbidities and mortalities. There is an utmost need for a new tool helping in early diagnosis and proper management of sepsis neonates. Neutrophil CD64 (nCD64) shows a very promising value in this concerning issue.
aimEvaluate the diagnostic, monitoring, and prognostic performances of nCD64 and highly sensitive CRP (hs-CRP) in NS as well as the possible best panel of biomarkers that can achieve the most desirable results.
methodsPatients were enrolled from three neonatal intensive care units (NICUs) (
resultsSignificant increase in nCD64 and hs-CRP results were present in sepsis groups compared to the disease controls (
conclusionBesides the promising diagnostic performance documented by nCD64 which is higher than the other laboratory sepsis biomarkers used routinely in NICUs, nCD64 has a valuable role in sepsis patients' monitoring and prognostic evaluation. hs-CRP was moderate in its diagnostic and monitoring results being less than that achieved by nCD64. Combined measurement of nCD64% and hs-CRP gives better diagnostic and monitoring performance than that achieved by any of them alone.
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