Evidence map›Paper›PMID 32832532›Full record

ArticleERJ open research2020

Management of solitary fibrous tumours of the pleura: a systematic review and meta-analysis.

Rachel M Mercer, Charlotte Wigston, Radhika Banka, Giuseppe Cardillo, Rachel Benamore, Andrew G Nicholson, Rachelle Asciak, Maged Hassan, Robert J Hallifax, Louise Wing and 5 more

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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  14. Annals of nuclear medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Rachel M MercerUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Charlotte WigstonUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Radhika BankaUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Giuseppe CardilloSan Camillo Forlanini Hospital, Rome, Italy.
Rachel BenamoreUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Andrew G NicholsonDept of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, and National Heart and Lung Institute, Imperial College, London, UK.
Rachelle AsciakUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Maged HassanUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.ORCID https://orcid.org/0000-0002-8768-6548
Robert J HallifaxUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Louise WingUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Eihab O BedawiUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.ORCID https://orcid.org/0000-0001-9196-3934
Nick A MaskellAcademic Respiratory Unit, Bristol Medical School, Southmead Hospital, University of Bristol, Bristol, UK.
Elinor K HarrissBodleian Health Care Libraries, University of Oxford, Oxford, UK.
Robert F MillerInstitute for Global Health, University College London, London, UK.
Najib M RahmanUniversity of Oxford Respiratory Trials Unit, Churchill Hospital, Oxford, UK.
Churchill Hospital · GBCarlo Forlanini Hospital · ITRoyal Brompton & Harefield NHS Foundation Trust · GBSouthmead Hospital · GBUniversity College London · GBUniversity of Oxford · GB

Funding

Marie Curie MCCC-RP-14-A17178
6 · The paper itself

Abstract

backgroundSolitary fibrous tumours of the pleura (SFTP), or pleural fibromas, are rare tumours that generally, but not universally, follow a benign course. Surgical resection is the standard treatment, but there are no evidence-based guidelines regarding the management of these tumours.

methodsFive databases were searched from inception to April 1, 2019 for studies reporting on SFTP management.

resultsTwenty-seven studies met the inclusion criteria (1542 patients, all non-comparative case series); 98% of these patients underwent resection and all SFTP included were pathologically diagnosed. 394 out of 1299 cases (30.5%, 95% CI 27.8-32.8%) were malignant with recurrence rates of between 0% and 42.9%. A pleural effusion was always associated with a negative outcome, but no other features were consistently reported to have negative associations. Preoperative biopsies incorrectly reported malignant histology in two studies. Over 25% of cases of recurrence occurred when a complete (R0) resection had been achieved. The first recurrence occurred >5 years after the initial resection in at least 23% of cases.

conclusionsThere is strong evidence to support long-term surveillance after surgical resection of SFTP, even where a complete (R0) resection has been achieved; however, there is no clear evidence to inform clinicians regarding the selection of patients who should undergo resection. The rates of malignant SFTP and SFTP recurrence are higher than previously reported. Only those that were pathologically diagnosed or resected were included, which may bias the data towards more aggressive tumours. Data collection on radiologically diagnosed SFTP is required to draw conclusions regarding the timing and need for intervention.

Identifiers

PMID32832532
PMCPMC7430150
OpenAlexW3049751208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.