ArticleERJ open research2020
Physiological signature of late-onset nonallergic asthma of obesity.
Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- A randomized trial of continuous positive airway pressure for the asthma of obesity.Respiratory research · 2025Trial
- Impact of Insulin Resistance on Asthma: Is There Truly No Role of "Obesity"?American journal of respiratory and critical care medicine · 2023Article
- Fraction of exhaled nitric oxide is associated with disease burden in the German Asthma Net severe asthma cohort.The European respiratory journal · 2022Article
- Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Air Trapping versus Atelectasis in Obesity: Relationship to Late-Onset Nonallergic Asthma and Aging.Annals of the American Thoracic Society · 2022Article
- Positive expiratory pressure: a potential therapy to mitigate acute bronchoconstriction in the asthma of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Altered airway mechanics in the context of obesity and asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionObesity can lead to a late-onset nonallergic (LONA) form of asthma for reasons that are not understood. We sought to determine whether this form of asthma is characterised by any unique physiological features.
methodsSpirometry, body plethysmography, multiple breath nitrogen washout (MBNW) and methacholine challenge were performed in four subject groups: Lean Control (n=11), Lean Asthma (n=11), Obese Control (n=11) and LONA Obese Asthma (n=10). The MBNW data were fitted with a novel computational model that estimates functional residual capacity (FRC), dead space volume (V
resultsBody mass index and waist circumference values were similar in both obese groups, and significantly greater than in lean asthmatic individuals and controls. Forced vital capacity was significantly lower in the LONA Asthma group compared with the other groups (p<0.001). Both asthma groups exhibited similar hyperresponsiveness to methacholine. FRC was reduced in the Obese LONA Asthma group as measured by MBNW, but not in obese controls, whereas FRC was reduced in both obese groups as measured by plethysmography. V
conclusionsChronic lung compression characterises all obese subjects, as reflected by reduced plethysmographic FRC. Obese LONA asthma is characterised by a reduced ability to recruit closed lung units, as seen by reduced MBNW FRC, and an increased tendency for airway closure as seen by a reduced forced vital capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.